Targeted Regeneration of Bone in the Osteoporotic Human Femur

We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. A...

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Detalles Bibliográficos
Autores principales: Poole, Kenneth E. S., Treece, Graham M., Ridgway, Gerard R., Mayhew, Paul M., Borggrefe, Jan, Gee, Andrew H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021547/
https://www.ncbi.nlm.nih.gov/pubmed/21264263
http://dx.doi.org/10.1371/journal.pone.0016190
Descripción
Sumario:We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.

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