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Targeted Regeneration of Bone in the Osteoporotic Human Femur

We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. A...

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Detalles Bibliográficos
Autores principales: Poole, Kenneth E. S., Treece, Graham M., Ridgway, Gerard R., Mayhew, Paul M., Borggrefe, Jan, Gee, Andrew H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021547/
https://www.ncbi.nlm.nih.gov/pubmed/21264263
http://dx.doi.org/10.1371/journal.pone.0016190
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author Poole, Kenneth E. S.
Treece, Graham M.
Ridgway, Gerard R.
Mayhew, Paul M.
Borggrefe, Jan
Gee, Andrew H.
author_facet Poole, Kenneth E. S.
Treece, Graham M.
Ridgway, Gerard R.
Mayhew, Paul M.
Borggrefe, Jan
Gee, Andrew H.
author_sort Poole, Kenneth E. S.
collection PubMed
description We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.
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spelling pubmed-30215472011-01-24 Targeted Regeneration of Bone in the Osteoporotic Human Femur Poole, Kenneth E. S. Treece, Graham M. Ridgway, Gerard R. Mayhew, Paul M. Borggrefe, Jan Gee, Andrew H. PLoS One Research Article We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness. Public Library of Science 2011-01-14 /pmc/articles/PMC3021547/ /pubmed/21264263 http://dx.doi.org/10.1371/journal.pone.0016190 Text en Poole et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Poole, Kenneth E. S.
Treece, Graham M.
Ridgway, Gerard R.
Mayhew, Paul M.
Borggrefe, Jan
Gee, Andrew H.
Targeted Regeneration of Bone in the Osteoporotic Human Femur
title Targeted Regeneration of Bone in the Osteoporotic Human Femur
title_full Targeted Regeneration of Bone in the Osteoporotic Human Femur
title_fullStr Targeted Regeneration of Bone in the Osteoporotic Human Femur
title_full_unstemmed Targeted Regeneration of Bone in the Osteoporotic Human Femur
title_short Targeted Regeneration of Bone in the Osteoporotic Human Femur
title_sort targeted regeneration of bone in the osteoporotic human femur
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021547/
https://www.ncbi.nlm.nih.gov/pubmed/21264263
http://dx.doi.org/10.1371/journal.pone.0016190
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