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Targeted Regeneration of Bone in the Osteoporotic Human Femur
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. A...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021547/ https://www.ncbi.nlm.nih.gov/pubmed/21264263 http://dx.doi.org/10.1371/journal.pone.0016190 |
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author | Poole, Kenneth E. S. Treece, Graham M. Ridgway, Gerard R. Mayhew, Paul M. Borggrefe, Jan Gee, Andrew H. |
author_facet | Poole, Kenneth E. S. Treece, Graham M. Ridgway, Gerard R. Mayhew, Paul M. Borggrefe, Jan Gee, Andrew H. |
author_sort | Poole, Kenneth E. S. |
collection | PubMed |
description | We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness. |
format | Text |
id | pubmed-3021547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30215472011-01-24 Targeted Regeneration of Bone in the Osteoporotic Human Femur Poole, Kenneth E. S. Treece, Graham M. Ridgway, Gerard R. Mayhew, Paul M. Borggrefe, Jan Gee, Andrew H. PLoS One Research Article We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness. Public Library of Science 2011-01-14 /pmc/articles/PMC3021547/ /pubmed/21264263 http://dx.doi.org/10.1371/journal.pone.0016190 Text en Poole et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Poole, Kenneth E. S. Treece, Graham M. Ridgway, Gerard R. Mayhew, Paul M. Borggrefe, Jan Gee, Andrew H. Targeted Regeneration of Bone in the Osteoporotic Human Femur |
title | Targeted Regeneration of Bone in the Osteoporotic Human Femur |
title_full | Targeted Regeneration of Bone in the Osteoporotic Human Femur |
title_fullStr | Targeted Regeneration of Bone in the Osteoporotic Human Femur |
title_full_unstemmed | Targeted Regeneration of Bone in the Osteoporotic Human Femur |
title_short | Targeted Regeneration of Bone in the Osteoporotic Human Femur |
title_sort | targeted regeneration of bone in the osteoporotic human femur |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021547/ https://www.ncbi.nlm.nih.gov/pubmed/21264263 http://dx.doi.org/10.1371/journal.pone.0016190 |
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