Formulation and Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride

The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization...

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Detalles Bibliográficos
Autores principales: Patil, SA, Kuchekar, BS, Chabukswar, AR, Jagdale, SC
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Pharmaceutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021685/
https://www.ncbi.nlm.nih.gov/pubmed/21264113
http://dx.doi.org/10.4103/0975-1483.63147
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author Patil, SA
Kuchekar, BS
Chabukswar, AR
Jagdale, SC
author_facet Patil, SA
Kuchekar, BS
Chabukswar, AR
Jagdale, SC
author_sort Patil, SA
collection PubMed
description The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calorimetry and X-ray powder diffractometry. The optimized formulation was subjected to accelerated stability testing as per ICH guidelines. Release data were examined kinetically. SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin.
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spelling pubmed-30216852011-01-24 Formulation and Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride Patil, SA Kuchekar, BS Chabukswar, AR Jagdale, SC J Young Pharm Pharmaceutics The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calorimetry and X-ray powder diffractometry. The optimized formulation was subjected to accelerated stability testing as per ICH guidelines. Release data were examined kinetically. SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin. Medknow Publications 2010 /pmc/articles/PMC3021685/ /pubmed/21264113 http://dx.doi.org/10.4103/0975-1483.63147 Text en © Journal of Young Pharmacists https://creativecommons.org/licenses/by/2.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Pharmaceutics
Patil, SA
Kuchekar, BS
Chabukswar, AR
Jagdale, SC
Formulation and Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride
title Formulation and Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride
title_full Formulation and Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride
title_fullStr Formulation and Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride
title_full_unstemmed Formulation and Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride
title_short Formulation and Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride
title_sort formulation and evaluation of extended-release solid dispersion of metformin hydrochloride
topic Pharmaceutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021685/
https://www.ncbi.nlm.nih.gov/pubmed/21264113
http://dx.doi.org/10.4103/0975-1483.63147
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AT kuchekarbs formulationandevaluationofextendedreleasesoliddispersionofmetforminhydrochloride
AT chabukswarar formulationandevaluationofextendedreleasesoliddispersionofmetforminhydrochloride
AT jagdalesc formulationandevaluationofextendedreleasesoliddispersionofmetforminhydrochloride

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