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Possible Role of Hydrogen Sulfide in Insulin Secretion and in Development of Insulin Resistance
H(2)S has been proposed as physiological important molecule. It is considered as first endogenous gaseous K(+) channel opener. K(+) ATP channel activity is mainly responsible for insulin secretion. K(+)ATP channel opening of β cells leads to inhibition of insulin secretion and channels closing leads...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021689/ https://www.ncbi.nlm.nih.gov/pubmed/21264117 http://dx.doi.org/10.4103/0975-1483.63156 |
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author | Patel, MA Shah, GB |
author_facet | Patel, MA Shah, GB |
author_sort | Patel, MA |
collection | PubMed |
description | H(2)S has been proposed as physiological important molecule. It is considered as first endogenous gaseous K(+) channel opener. K(+) ATP channel activity is mainly responsible for insulin secretion. K(+)ATP channel opening of β cells leads to inhibition of insulin secretion and channels closing leads to secretion. H2S is the gaseous K(+) ATP channel opener but it does not have channel specificity. So, H(2)S may have some effect on insulin secretion. H(2)S is high in Zuker diabetic fatty rats. That means H(2)S is high in insulin resistance condition. We tried to find out the role of H(2)S in insulin secretion and in development of insulin resistance. From the result of our study, H(2)S have K(+) ATP channel opening activity on β cells. H(2)S does not have any role in the development of insulin resistance. Decrease in insulin level in Zuker diabetic rat and streptozotocin-induced diabetic rat is due to high H(2)S level. |
format | Text |
id | pubmed-3021689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-30216892011-01-24 Possible Role of Hydrogen Sulfide in Insulin Secretion and in Development of Insulin Resistance Patel, MA Shah, GB J Young Pharm Pharmacology H(2)S has been proposed as physiological important molecule. It is considered as first endogenous gaseous K(+) channel opener. K(+) ATP channel activity is mainly responsible for insulin secretion. K(+)ATP channel opening of β cells leads to inhibition of insulin secretion and channels closing leads to secretion. H2S is the gaseous K(+) ATP channel opener but it does not have channel specificity. So, H(2)S may have some effect on insulin secretion. H(2)S is high in Zuker diabetic fatty rats. That means H(2)S is high in insulin resistance condition. We tried to find out the role of H(2)S in insulin secretion and in development of insulin resistance. From the result of our study, H(2)S have K(+) ATP channel opening activity on β cells. H(2)S does not have any role in the development of insulin resistance. Decrease in insulin level in Zuker diabetic rat and streptozotocin-induced diabetic rat is due to high H(2)S level. Medknow Publications 2010 /pmc/articles/PMC3021689/ /pubmed/21264117 http://dx.doi.org/10.4103/0975-1483.63156 Text en © Journal of Young Pharmacists http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Pharmacology Patel, MA Shah, GB Possible Role of Hydrogen Sulfide in Insulin Secretion and in Development of Insulin Resistance |
title | Possible Role of Hydrogen Sulfide in Insulin Secretion and in Development of Insulin Resistance |
title_full | Possible Role of Hydrogen Sulfide in Insulin Secretion and in Development of Insulin Resistance |
title_fullStr | Possible Role of Hydrogen Sulfide in Insulin Secretion and in Development of Insulin Resistance |
title_full_unstemmed | Possible Role of Hydrogen Sulfide in Insulin Secretion and in Development of Insulin Resistance |
title_short | Possible Role of Hydrogen Sulfide in Insulin Secretion and in Development of Insulin Resistance |
title_sort | possible role of hydrogen sulfide in insulin secretion and in development of insulin resistance |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021689/ https://www.ncbi.nlm.nih.gov/pubmed/21264117 http://dx.doi.org/10.4103/0975-1483.63156 |
work_keys_str_mv | AT patelma possibleroleofhydrogensulfideininsulinsecretionandindevelopmentofinsulinresistance AT shahgb possibleroleofhydrogensulfideininsulinsecretionandindevelopmentofinsulinresistance |