Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one

In our study, a series of novel 3-(4-(benzylideneamino) phenylimino) 4-fluoroindolin-2-one derivatives were synthesized and characterized by spectral (I.R, (1)H NMR, mass) and elemental analysis. The title compounds (N(1)-N(10)) were evaluated for analgesic, anti-inflammatory, and ulcerogenic index...

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Detalles Bibliográficos
Autores principales: Nirmal, R, Prakash, CR, Meenakshi, K, Shanmugapandiyan, P
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Pharmaceutical Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021692/
https://www.ncbi.nlm.nih.gov/pubmed/21264120
http://dx.doi.org/10.4103/0975-1483.63162
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author Nirmal, R
Prakash, CR
Meenakshi, K
Shanmugapandiyan, P
author_facet Nirmal, R
Prakash, CR
Meenakshi, K
Shanmugapandiyan, P
author_sort Nirmal, R
collection PubMed
description In our study, a series of novel 3-(4-(benzylideneamino) phenylimino) 4-fluoroindolin-2-one derivatives were synthesized and characterized by spectral (I.R, (1)H NMR, mass) and elemental analysis. The title compounds (N(1)-N(10)) were evaluated for analgesic, anti-inflammatory, and ulcerogenic index activities. Results displayed that compound N(3) exhibited significant analgesic activity. Among the title compounds studied, N(2), N(3), and N(8) exhibited significant anti- inflammatory activity comparable to reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic side effect when compared to aspirin.
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spelling pubmed-30216922011-01-24 Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one Nirmal, R Prakash, CR Meenakshi, K Shanmugapandiyan, P J Young Pharm Pharmaceutical Chemistry In our study, a series of novel 3-(4-(benzylideneamino) phenylimino) 4-fluoroindolin-2-one derivatives were synthesized and characterized by spectral (I.R, (1)H NMR, mass) and elemental analysis. The title compounds (N(1)-N(10)) were evaluated for analgesic, anti-inflammatory, and ulcerogenic index activities. Results displayed that compound N(3) exhibited significant analgesic activity. Among the title compounds studied, N(2), N(3), and N(8) exhibited significant anti- inflammatory activity comparable to reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic side effect when compared to aspirin. Medknow Publications 2010 /pmc/articles/PMC3021692/ /pubmed/21264120 http://dx.doi.org/10.4103/0975-1483.63162 Text en © Journal of Young Pharmacists http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Pharmaceutical Chemistry
Nirmal, R
Prakash, CR
Meenakshi, K
Shanmugapandiyan, P
Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one
title Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one
title_full Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one
title_fullStr Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one
title_full_unstemmed Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one
title_short Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one
title_sort synthesis and pharmacological evaluation of novel schiff base analogues of 3-(4-amino) phenylimino) 5-fluoroindolin-2-one
topic Pharmaceutical Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021692/
https://www.ncbi.nlm.nih.gov/pubmed/21264120
http://dx.doi.org/10.4103/0975-1483.63162
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AT meenakshik synthesisandpharmacologicalevaluationofnovelschiffbaseanaloguesof34aminophenylimino5fluoroindolin2one
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