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Accelerated Cardiac Magnetic Resonance Imaging in the Mouse Using an Eight-Channel Array at 9.4 Tesla

MRI has become an important tool to noninvasively assess global and regional cardiac function, infarct size, or myocardial blood flow in surgically or genetically modified mouse models of human heart disease. Constraints on scan time due to sensitivity to general anesthesia in hemodynamically compro...

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Autores principales: Schneider, Jürgen E, Lanz, Titus, Barnes, Hannah, Stork, Lee-Anne, Bohl, Steffen, Lygate, Craig A, Ordidge, Roger J, Neubauer, Stefan
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021721/
https://www.ncbi.nlm.nih.gov/pubmed/20740650
http://dx.doi.org/10.1002/mrm.22605
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author Schneider, Jürgen E
Lanz, Titus
Barnes, Hannah
Stork, Lee-Anne
Bohl, Steffen
Lygate, Craig A
Ordidge, Roger J
Neubauer, Stefan
author_facet Schneider, Jürgen E
Lanz, Titus
Barnes, Hannah
Stork, Lee-Anne
Bohl, Steffen
Lygate, Craig A
Ordidge, Roger J
Neubauer, Stefan
author_sort Schneider, Jürgen E
collection PubMed
description MRI has become an important tool to noninvasively assess global and regional cardiac function, infarct size, or myocardial blood flow in surgically or genetically modified mouse models of human heart disease. Constraints on scan time due to sensitivity to general anesthesia in hemodynamically compromised mice frequently limit the number of parameters available in one imaging session. Parallel imaging techniques to reduce acquisition times require coil arrays, which are technically challenging to design at ultrahigh magnetic field strengths. This work validates the use of an eight-channel volume phased-array coil for cardiac MRI in mice at 9.4 T. Two- and three-dimensional sequences were combined with parallel imaging techniques and used to quantify global cardiac function, T(1)-relaxation times and infarct sizes. Furthermore, the rapid acquisition of functional cine-data allowed for the first time in mice measurement of left-ventricular peak filling and ejection rates under intravenous infusion of dobutamine. The results demonstrate that a threefold accelerated data acquisition is generally feasible without compromising the accuracy of the results. This strategy may eventually pave the way for routine, multiparametric phenotyping of mouse hearts in vivo within one imaging session of tolerable duration. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc.
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spelling pubmed-30217212011-01-18 Accelerated Cardiac Magnetic Resonance Imaging in the Mouse Using an Eight-Channel Array at 9.4 Tesla Schneider, Jürgen E Lanz, Titus Barnes, Hannah Stork, Lee-Anne Bohl, Steffen Lygate, Craig A Ordidge, Roger J Neubauer, Stefan Magn Reson Med Full Paper MRI has become an important tool to noninvasively assess global and regional cardiac function, infarct size, or myocardial blood flow in surgically or genetically modified mouse models of human heart disease. Constraints on scan time due to sensitivity to general anesthesia in hemodynamically compromised mice frequently limit the number of parameters available in one imaging session. Parallel imaging techniques to reduce acquisition times require coil arrays, which are technically challenging to design at ultrahigh magnetic field strengths. This work validates the use of an eight-channel volume phased-array coil for cardiac MRI in mice at 9.4 T. Two- and three-dimensional sequences were combined with parallel imaging techniques and used to quantify global cardiac function, T(1)-relaxation times and infarct sizes. Furthermore, the rapid acquisition of functional cine-data allowed for the first time in mice measurement of left-ventricular peak filling and ejection rates under intravenous infusion of dobutamine. The results demonstrate that a threefold accelerated data acquisition is generally feasible without compromising the accuracy of the results. This strategy may eventually pave the way for routine, multiparametric phenotyping of mouse hearts in vivo within one imaging session of tolerable duration. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc. Wiley Subscription Services, Inc., A Wiley Company 2011-01 2010-08-25 /pmc/articles/PMC3021721/ /pubmed/20740650 http://dx.doi.org/10.1002/mrm.22605 Text en Copyright © 2010 Wiley-Liss, Inc., A Wiley Company http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Full Paper
Schneider, Jürgen E
Lanz, Titus
Barnes, Hannah
Stork, Lee-Anne
Bohl, Steffen
Lygate, Craig A
Ordidge, Roger J
Neubauer, Stefan
Accelerated Cardiac Magnetic Resonance Imaging in the Mouse Using an Eight-Channel Array at 9.4 Tesla
title Accelerated Cardiac Magnetic Resonance Imaging in the Mouse Using an Eight-Channel Array at 9.4 Tesla
title_full Accelerated Cardiac Magnetic Resonance Imaging in the Mouse Using an Eight-Channel Array at 9.4 Tesla
title_fullStr Accelerated Cardiac Magnetic Resonance Imaging in the Mouse Using an Eight-Channel Array at 9.4 Tesla
title_full_unstemmed Accelerated Cardiac Magnetic Resonance Imaging in the Mouse Using an Eight-Channel Array at 9.4 Tesla
title_short Accelerated Cardiac Magnetic Resonance Imaging in the Mouse Using an Eight-Channel Array at 9.4 Tesla
title_sort accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 tesla
topic Full Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021721/
https://www.ncbi.nlm.nih.gov/pubmed/20740650
http://dx.doi.org/10.1002/mrm.22605
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