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Neonatal innate immunity and Toll-like receptor
The innate immune response is the first line of defense against microbial infections. Innate immunity is made up of the surface barrier, cellular immunity and humoral immunity. In newborn, immunologic function and demands are different to adults. Neonatal innate immunity specifically suppresses Th1-...
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Formato: | Texto |
Lenguaje: | English |
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The Korean Pediatric Society
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021731/ https://www.ncbi.nlm.nih.gov/pubmed/21253311 http://dx.doi.org/10.3345/kjp.2010.53.12.985 |
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author | Yoon, Hye Sun |
author_facet | Yoon, Hye Sun |
author_sort | Yoon, Hye Sun |
collection | PubMed |
description | The innate immune response is the first line of defense against microbial infections. Innate immunity is made up of the surface barrier, cellular immunity and humoral immunity. In newborn, immunologic function and demands are different to adults. Neonatal innate immunity specifically suppresses Th1-type immune responses, and not Th2-type immune responses, which are enhanced. And the impaired response of macrophages is associated with the defective innate immunity in newborn period. Toll-like receptors (TLRs) play a key roles in the detection of invading pathogens and in the induction of innate immune responses. In newborn, the expression of TLRs is age dependent, so preterm has low expression of TLRs. Also, there are defects in signaling pathways downstream of TLRs. As a consequence, the defects of TLRs activity cause the susceptibility to infection in the neonatal period. |
format | Text |
id | pubmed-3021731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Pediatric Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-30217312011-01-20 Neonatal innate immunity and Toll-like receptor Yoon, Hye Sun Korean J Pediatr Review Article The innate immune response is the first line of defense against microbial infections. Innate immunity is made up of the surface barrier, cellular immunity and humoral immunity. In newborn, immunologic function and demands are different to adults. Neonatal innate immunity specifically suppresses Th1-type immune responses, and not Th2-type immune responses, which are enhanced. And the impaired response of macrophages is associated with the defective innate immunity in newborn period. Toll-like receptors (TLRs) play a key roles in the detection of invading pathogens and in the induction of innate immune responses. In newborn, the expression of TLRs is age dependent, so preterm has low expression of TLRs. Also, there are defects in signaling pathways downstream of TLRs. As a consequence, the defects of TLRs activity cause the susceptibility to infection in the neonatal period. The Korean Pediatric Society 2010-12 2010-12-31 /pmc/articles/PMC3021731/ /pubmed/21253311 http://dx.doi.org/10.3345/kjp.2010.53.12.985 Text en Copyright © 2010 by The Korean Pediatric Society http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yoon, Hye Sun Neonatal innate immunity and Toll-like receptor |
title | Neonatal innate immunity and Toll-like receptor |
title_full | Neonatal innate immunity and Toll-like receptor |
title_fullStr | Neonatal innate immunity and Toll-like receptor |
title_full_unstemmed | Neonatal innate immunity and Toll-like receptor |
title_short | Neonatal innate immunity and Toll-like receptor |
title_sort | neonatal innate immunity and toll-like receptor |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021731/ https://www.ncbi.nlm.nih.gov/pubmed/21253311 http://dx.doi.org/10.3345/kjp.2010.53.12.985 |
work_keys_str_mv | AT yoonhyesun neonatalinnateimmunityandtolllikereceptor |