A Factor Analytic Approach to Symptom Patterns in Dementia

Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform...

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Autores principales: Gustafson, Lars, Erikson, Catarina, Warkentin, Siegbert, Brun, Arne, Englund, Elisabet, Passant, Ulla
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021844/
https://www.ncbi.nlm.nih.gov/pubmed/21253531
http://dx.doi.org/10.4061/2011/632604
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author Gustafson, Lars
Erikson, Catarina
Warkentin, Siegbert
Brun, Arne
Englund, Elisabet
Passant, Ulla
author_facet Gustafson, Lars
Erikson, Catarina
Warkentin, Siegbert
Brun, Arne
Englund, Elisabet
Passant, Ulla
author_sort Gustafson, Lars
collection PubMed
description Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform an exploratory factor analysis of the items in these clinical rating scales. The study included 190 patients with postmortem diagnoses of AD (n = 74), VaD (n = 33), mixed AD/VaD (n = 31), or FTD (n = 52). The factor analysis produced three strong factors. Factor 1 contained items describing cerebrovascular disease, similar to the Hachinski Ischemic Score. Factor 2 enclosed major clinical characteristics of FTD, and factor 3 showed a striking similarity to the AD scale. A fourth symptom cluster was described by perception and expression of emotions. The factor analyses strongly support the construct validity of the diagnostic rating scales.
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spelling pubmed-30218442011-01-20 A Factor Analytic Approach to Symptom Patterns in Dementia Gustafson, Lars Erikson, Catarina Warkentin, Siegbert Brun, Arne Englund, Elisabet Passant, Ulla Int J Alzheimers Dis Research Article Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform an exploratory factor analysis of the items in these clinical rating scales. The study included 190 patients with postmortem diagnoses of AD (n = 74), VaD (n = 33), mixed AD/VaD (n = 31), or FTD (n = 52). The factor analysis produced three strong factors. Factor 1 contained items describing cerebrovascular disease, similar to the Hachinski Ischemic Score. Factor 2 enclosed major clinical characteristics of FTD, and factor 3 showed a striking similarity to the AD scale. A fourth symptom cluster was described by perception and expression of emotions. The factor analyses strongly support the construct validity of the diagnostic rating scales. SAGE-Hindawi Access to Research 2010-12-30 /pmc/articles/PMC3021844/ /pubmed/21253531 http://dx.doi.org/10.4061/2011/632604 Text en Copyright © 2011 Lars Gustafson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gustafson, Lars
Erikson, Catarina
Warkentin, Siegbert
Brun, Arne
Englund, Elisabet
Passant, Ulla
A Factor Analytic Approach to Symptom Patterns in Dementia
title A Factor Analytic Approach to Symptom Patterns in Dementia
title_full A Factor Analytic Approach to Symptom Patterns in Dementia
title_fullStr A Factor Analytic Approach to Symptom Patterns in Dementia
title_full_unstemmed A Factor Analytic Approach to Symptom Patterns in Dementia
title_short A Factor Analytic Approach to Symptom Patterns in Dementia
title_sort factor analytic approach to symptom patterns in dementia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021844/
https://www.ncbi.nlm.nih.gov/pubmed/21253531
http://dx.doi.org/10.4061/2011/632604
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