Short-Term Prognostic Index for Breast Cancer: NPI or Lpi

Axillary lymph node involvement is an important prognostic factor for breast cancer survival but is confounded by the number of nodes examined. We compare the performance of the log odds prognostic index (Lpi), using a ratio of the positive versus negative lymph nodes, with the Nottingham Prognostic...

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Autores principales: Van Belle, V., Decock, J., Hendrickx, W., Brouckaert, O., Pintens, S., Moerman, P., Wildiers, H., Paridaens, R., Christiaens, M. R., Van Huffel, S., Neven, P.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021876/
https://www.ncbi.nlm.nih.gov/pubmed/21253502
http://dx.doi.org/10.4061/2011/918408
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author Van Belle, V.
Decock, J.
Hendrickx, W.
Brouckaert, O.
Pintens, S.
Moerman, P.
Wildiers, H.
Paridaens, R.
Christiaens, M. R.
Van Huffel, S.
Neven, P.
author_facet Van Belle, V.
Decock, J.
Hendrickx, W.
Brouckaert, O.
Pintens, S.
Moerman, P.
Wildiers, H.
Paridaens, R.
Christiaens, M. R.
Van Huffel, S.
Neven, P.
author_sort Van Belle, V.
collection PubMed
description Axillary lymph node involvement is an important prognostic factor for breast cancer survival but is confounded by the number of nodes examined. We compare the performance of the log odds prognostic index (Lpi), using a ratio of the positive versus negative lymph nodes, with the Nottingham Prognostic Index (NPI) for short-term breast cancer specific disease free survival. A total of 1818 operable breast cancer patients treated in the University Hospital of Leuven between 2000 and 2005 were included. The performance of the NPI and Lpi were compared on two levels: calibration and discrimination. The latter was evaluated using the concordance index (cindex), the number of patients in the extreme groups, and difference in event rates between these. The NPI had a significant higher cindex, but a significant lower percentage of patients in the extreme risk groups. After updating both indices, no significant differences between NPI and Lpi were noted.
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spelling pubmed-30218762011-01-20 Short-Term Prognostic Index for Breast Cancer: NPI or Lpi Van Belle, V. Decock, J. Hendrickx, W. Brouckaert, O. Pintens, S. Moerman, P. Wildiers, H. Paridaens, R. Christiaens, M. R. Van Huffel, S. Neven, P. Patholog Res Int Research Article Axillary lymph node involvement is an important prognostic factor for breast cancer survival but is confounded by the number of nodes examined. We compare the performance of the log odds prognostic index (Lpi), using a ratio of the positive versus negative lymph nodes, with the Nottingham Prognostic Index (NPI) for short-term breast cancer specific disease free survival. A total of 1818 operable breast cancer patients treated in the University Hospital of Leuven between 2000 and 2005 were included. The performance of the NPI and Lpi were compared on two levels: calibration and discrimination. The latter was evaluated using the concordance index (cindex), the number of patients in the extreme groups, and difference in event rates between these. The NPI had a significant higher cindex, but a significant lower percentage of patients in the extreme risk groups. After updating both indices, no significant differences between NPI and Lpi were noted. SAGE-Hindawi Access to Research 2010-12-28 /pmc/articles/PMC3021876/ /pubmed/21253502 http://dx.doi.org/10.4061/2011/918408 Text en Copyright © 2011 V. Van Belle et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Van Belle, V.
Decock, J.
Hendrickx, W.
Brouckaert, O.
Pintens, S.
Moerman, P.
Wildiers, H.
Paridaens, R.
Christiaens, M. R.
Van Huffel, S.
Neven, P.
Short-Term Prognostic Index for Breast Cancer: NPI or Lpi
title Short-Term Prognostic Index for Breast Cancer: NPI or Lpi
title_full Short-Term Prognostic Index for Breast Cancer: NPI or Lpi
title_fullStr Short-Term Prognostic Index for Breast Cancer: NPI or Lpi
title_full_unstemmed Short-Term Prognostic Index for Breast Cancer: NPI or Lpi
title_short Short-Term Prognostic Index for Breast Cancer: NPI or Lpi
title_sort short-term prognostic index for breast cancer: npi or lpi
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021876/
https://www.ncbi.nlm.nih.gov/pubmed/21253502
http://dx.doi.org/10.4061/2011/918408
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