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High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism

The essential trace element selenium has long been considered to exhibit anti-diabetic and insulin-mimetic properties, but recent epidemiological studies indicated supranutritional selenium intake and high plasma selenium levels as possible risk factors for development of type 2 diabetes, pointing t...

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Autores principales: Steinbrenner, Holger, Speckmann, Bodo, Pinto, Antonio, Sies, Helmut
Formato: Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022062/
https://www.ncbi.nlm.nih.gov/pubmed/21297910
http://dx.doi.org/10.3164/jcbn.11-002FR
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author Steinbrenner, Holger
Speckmann, Bodo
Pinto, Antonio
Sies, Helmut
author_facet Steinbrenner, Holger
Speckmann, Bodo
Pinto, Antonio
Sies, Helmut
author_sort Steinbrenner, Holger
collection PubMed
description The essential trace element selenium has long been considered to exhibit anti-diabetic and insulin-mimetic properties, but recent epidemiological studies indicated supranutritional selenium intake and high plasma selenium levels as possible risk factors for development of type 2 diabetes, pointing to adverse effects of selenium on carbohydrate metabolism in humans. However, increased plasma selenium levels might be both a consequence and a cause of diabetes. We summarize current evidence for an interference of selenium compounds with insulin-regulated molecular pathways, most notably the phosphoinositide-3-kinase/protein kinase B signaling cascade, which may underlie some of the pro- and anti-diabetic actions of selenium. Furthermore, we discuss reports of hyperinsulinemia, hyperglycemia and insulin resistance in mice overexpressing the selenoenzyme glutathione peroxidase 1. The peroxisomal proliferator-activated receptor gamma coactivator 1α represents a key regulator for biosynthesis of the physiological selenium transporter, selenoprotein P, as well as for hepatic gluconeogenesis. As proliferator-activated receptor gamma coactivator 1α has been shown to be up-regulated in livers of diabetic animals and to promote insulin resistance, we hypothesize that dysregulated pathways in carbohydrate metabolism and a disturbance of selenium homeostasis are linked via proliferator-activated receptor gamma coactivator 1α.
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spelling pubmed-30220622011-02-04 High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism Steinbrenner, Holger Speckmann, Bodo Pinto, Antonio Sies, Helmut J Clin Biochem Nutr Review The essential trace element selenium has long been considered to exhibit anti-diabetic and insulin-mimetic properties, but recent epidemiological studies indicated supranutritional selenium intake and high plasma selenium levels as possible risk factors for development of type 2 diabetes, pointing to adverse effects of selenium on carbohydrate metabolism in humans. However, increased plasma selenium levels might be both a consequence and a cause of diabetes. We summarize current evidence for an interference of selenium compounds with insulin-regulated molecular pathways, most notably the phosphoinositide-3-kinase/protein kinase B signaling cascade, which may underlie some of the pro- and anti-diabetic actions of selenium. Furthermore, we discuss reports of hyperinsulinemia, hyperglycemia and insulin resistance in mice overexpressing the selenoenzyme glutathione peroxidase 1. The peroxisomal proliferator-activated receptor gamma coactivator 1α represents a key regulator for biosynthesis of the physiological selenium transporter, selenoprotein P, as well as for hepatic gluconeogenesis. As proliferator-activated receptor gamma coactivator 1α has been shown to be up-regulated in livers of diabetic animals and to promote insulin resistance, we hypothesize that dysregulated pathways in carbohydrate metabolism and a disturbance of selenium homeostasis are linked via proliferator-activated receptor gamma coactivator 1α. the Society for Free Radical Research Japan 2011-01 2010-12-28 /pmc/articles/PMC3022062/ /pubmed/21297910 http://dx.doi.org/10.3164/jcbn.11-002FR Text en Copyright © 2011 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Steinbrenner, Holger
Speckmann, Bodo
Pinto, Antonio
Sies, Helmut
High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism
title High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism
title_full High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism
title_fullStr High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism
title_full_unstemmed High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism
title_short High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism
title_sort high selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022062/
https://www.ncbi.nlm.nih.gov/pubmed/21297910
http://dx.doi.org/10.3164/jcbn.11-002FR
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