Regulation of Candida glabrata oxidative stress resistance is adapted to host environment

The human fungal pathogen Candida glabrata is related to Saccharomyces cerevisiae but has developed high resistance against reactive oxygen species. We find that induction of conserved genes encoding antioxidant functions is dependent on the transcription factors CgYap1 and CgSkn7 which cooperate fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Roetzer, Andreas, Klopf, Eva, Gratz, Nina, Marcet-Houben, Marina, Hiller, Ekkehard, Rupp, Steffen, Gabaldón, Toni, Kovarik, Pavel, Schüller, Christoph
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022126/
https://www.ncbi.nlm.nih.gov/pubmed/21156173
http://dx.doi.org/10.1016/j.febslet.2010.12.006
Descripción
Sumario:The human fungal pathogen Candida glabrata is related to Saccharomyces cerevisiae but has developed high resistance against reactive oxygen species. We find that induction of conserved genes encoding antioxidant functions is dependent on the transcription factors CgYap1 and CgSkn7 which cooperate for promoter recognition. Superoxide stress resistance of C. glabrata is provided by superoxide dismutase CgSod1, which is not dependent on CgYap1/Skn7. Only double mutants lacking both CgSod1 and CgYap1 were efficiently killed by primary mouse macrophages. Our results suggest that in C. glabrata the regulation of key genes providing stress protection is adopted to meet a host–pathogen situation.

Ejemplares similares