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Bone Marrow-Derived Mesenchymal Stem Cells: Current and Future Applications in the Urinary Bladder

Mesenchymal stem cells can be isolated from almost any adult tissue. In this paper we focus on bone marrow-derived mesenchymal stem cells which have captured the interest of researchers since their introduction because of the promising potential of tissue regeneration and repair. They are known for...

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Detalles Bibliográficos
Autores principales: Drzewiecki, Beth A., Thomas, John C., Tanaka, Stacy T.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022195/
https://www.ncbi.nlm.nih.gov/pubmed/21253479
http://dx.doi.org/10.4061/2010/765167
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author Drzewiecki, Beth A.
Thomas, John C.
Tanaka, Stacy T.
author_facet Drzewiecki, Beth A.
Thomas, John C.
Tanaka, Stacy T.
author_sort Drzewiecki, Beth A.
collection PubMed
description Mesenchymal stem cells can be isolated from almost any adult tissue. In this paper we focus on bone marrow-derived mesenchymal stem cells which have captured the interest of researchers since their introduction because of the promising potential of tissue regeneration and repair. They are known for their ability to self-renew and differentiate into diverse lineages while maintaining low immunogenicity. The exact mechanisms behind how these cells work still remain unclear, and there is a continuing shift in the paradigms that support them. There has been extensive research in multiple organ systems; however, the genitorurinary system has been vastly underrepresented. This article discusses the background behind bone marrow-derived mesenchymal stem cells and they are currently being applied to the urinary bladder in the realm of tissue engineering. We also postulate on their future applications based on the current literature in other organ systems.
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spelling pubmed-30221952011-01-20 Bone Marrow-Derived Mesenchymal Stem Cells: Current and Future Applications in the Urinary Bladder Drzewiecki, Beth A. Thomas, John C. Tanaka, Stacy T. Stem Cells Int Review Article Mesenchymal stem cells can be isolated from almost any adult tissue. In this paper we focus on bone marrow-derived mesenchymal stem cells which have captured the interest of researchers since their introduction because of the promising potential of tissue regeneration and repair. They are known for their ability to self-renew and differentiate into diverse lineages while maintaining low immunogenicity. The exact mechanisms behind how these cells work still remain unclear, and there is a continuing shift in the paradigms that support them. There has been extensive research in multiple organ systems; however, the genitorurinary system has been vastly underrepresented. This article discusses the background behind bone marrow-derived mesenchymal stem cells and they are currently being applied to the urinary bladder in the realm of tissue engineering. We also postulate on their future applications based on the current literature in other organ systems. SAGE-Hindawi Access to Research 2011-01-03 /pmc/articles/PMC3022195/ /pubmed/21253479 http://dx.doi.org/10.4061/2010/765167 Text en Copyright © 2010 Beth A. Drzewiecki et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Drzewiecki, Beth A.
Thomas, John C.
Tanaka, Stacy T.
Bone Marrow-Derived Mesenchymal Stem Cells: Current and Future Applications in the Urinary Bladder
title Bone Marrow-Derived Mesenchymal Stem Cells: Current and Future Applications in the Urinary Bladder
title_full Bone Marrow-Derived Mesenchymal Stem Cells: Current and Future Applications in the Urinary Bladder
title_fullStr Bone Marrow-Derived Mesenchymal Stem Cells: Current and Future Applications in the Urinary Bladder
title_full_unstemmed Bone Marrow-Derived Mesenchymal Stem Cells: Current and Future Applications in the Urinary Bladder
title_short Bone Marrow-Derived Mesenchymal Stem Cells: Current and Future Applications in the Urinary Bladder
title_sort bone marrow-derived mesenchymal stem cells: current and future applications in the urinary bladder
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022195/
https://www.ncbi.nlm.nih.gov/pubmed/21253479
http://dx.doi.org/10.4061/2010/765167
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