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Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals
Melicope ptelefolia is a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches. The present study was conducted to evaluate the antinociceptive activity of the Melicope ptelefolia ethanolic extract (MPEE) using animal models of nociception. The antinociceptive activity of...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022215/ https://www.ncbi.nlm.nih.gov/pubmed/21274262 http://dx.doi.org/10.1155/2010/937642 |
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author | Sulaiman, Mohd Roslan Mohd Padzil, Azyyati Shaari, Khozirah Khalid, Syamimi Shaik Mossadeq, Wan Mastura Mohamad, Azam Shah Ahmad, Syahida Akira, Ahmad Israf, Daud Lajis, Nordin |
author_facet | Sulaiman, Mohd Roslan Mohd Padzil, Azyyati Shaari, Khozirah Khalid, Syamimi Shaik Mossadeq, Wan Mastura Mohamad, Azam Shah Ahmad, Syahida Akira, Ahmad Israf, Daud Lajis, Nordin |
author_sort | Sulaiman, Mohd Roslan |
collection | PubMed |
description | Melicope ptelefolia is a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches. The present study was conducted to evaluate the antinociceptive activity of the Melicope ptelefolia ethanolic extract (MPEE) using animal models of nociception. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin-induced paw licking tests. Oral administration of MPEE produced significant dose-dependent antinociceptive effects when tested in mice and rats using acetic acid-induced abdominal constriction test and on the second phase of the formalin-induced paw licking test, respectively. It was also demonstrated that MPEE had no effect on the response latency time to the heat stimulus in the thermal model of the hot-plate test. In addition, the antinociception produced by MPEE was not blocked by naloxone. Furthermore, oral administration of MPEE did not produce any effect in motor performance of the rota-rod test and in acute toxicity study no abnormal behaviors as well as mortality were observed up to a dose level of the extract of 5 g/kg. These results indicated that MPEE at all doses investigated which did not produce any sedative and toxic effects exerted pronounce antinociceptive activity that acts peripherally in experimental animals. |
format | Text |
id | pubmed-3022215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30222152011-01-27 Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals Sulaiman, Mohd Roslan Mohd Padzil, Azyyati Shaari, Khozirah Khalid, Syamimi Shaik Mossadeq, Wan Mastura Mohamad, Azam Shah Ahmad, Syahida Akira, Ahmad Israf, Daud Lajis, Nordin J Biomed Biotechnol Research Article Melicope ptelefolia is a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches. The present study was conducted to evaluate the antinociceptive activity of the Melicope ptelefolia ethanolic extract (MPEE) using animal models of nociception. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin-induced paw licking tests. Oral administration of MPEE produced significant dose-dependent antinociceptive effects when tested in mice and rats using acetic acid-induced abdominal constriction test and on the second phase of the formalin-induced paw licking test, respectively. It was also demonstrated that MPEE had no effect on the response latency time to the heat stimulus in the thermal model of the hot-plate test. In addition, the antinociception produced by MPEE was not blocked by naloxone. Furthermore, oral administration of MPEE did not produce any effect in motor performance of the rota-rod test and in acute toxicity study no abnormal behaviors as well as mortality were observed up to a dose level of the extract of 5 g/kg. These results indicated that MPEE at all doses investigated which did not produce any sedative and toxic effects exerted pronounce antinociceptive activity that acts peripherally in experimental animals. Hindawi Publishing Corporation 2010 2011-01-02 /pmc/articles/PMC3022215/ /pubmed/21274262 http://dx.doi.org/10.1155/2010/937642 Text en Copyright © 2010 Mohd Roslan Sulaiman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sulaiman, Mohd Roslan Mohd Padzil, Azyyati Shaari, Khozirah Khalid, Syamimi Shaik Mossadeq, Wan Mastura Mohamad, Azam Shah Ahmad, Syahida Akira, Ahmad Israf, Daud Lajis, Nordin Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals |
title | Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals |
title_full | Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals |
title_fullStr | Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals |
title_full_unstemmed | Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals |
title_short | Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals |
title_sort | antinociceptive activity of melicope ptelefolia ethanolic extract in experimental animals |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022215/ https://www.ncbi.nlm.nih.gov/pubmed/21274262 http://dx.doi.org/10.1155/2010/937642 |
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