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Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals

Melicope ptelefolia is a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches. The present study was conducted to evaluate the antinociceptive activity of the Melicope ptelefolia ethanolic extract (MPEE) using animal models of nociception. The antinociceptive activity of...

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Autores principales: Sulaiman, Mohd Roslan, Mohd Padzil, Azyyati, Shaari, Khozirah, Khalid, Syamimi, Shaik Mossadeq, Wan Mastura, Mohamad, Azam Shah, Ahmad, Syahida, Akira, Ahmad, Israf, Daud, Lajis, Nordin
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022215/
https://www.ncbi.nlm.nih.gov/pubmed/21274262
http://dx.doi.org/10.1155/2010/937642
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author Sulaiman, Mohd Roslan
Mohd Padzil, Azyyati
Shaari, Khozirah
Khalid, Syamimi
Shaik Mossadeq, Wan Mastura
Mohamad, Azam Shah
Ahmad, Syahida
Akira, Ahmad
Israf, Daud
Lajis, Nordin
author_facet Sulaiman, Mohd Roslan
Mohd Padzil, Azyyati
Shaari, Khozirah
Khalid, Syamimi
Shaik Mossadeq, Wan Mastura
Mohamad, Azam Shah
Ahmad, Syahida
Akira, Ahmad
Israf, Daud
Lajis, Nordin
author_sort Sulaiman, Mohd Roslan
collection PubMed
description Melicope ptelefolia is a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches. The present study was conducted to evaluate the antinociceptive activity of the Melicope ptelefolia ethanolic extract (MPEE) using animal models of nociception. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin-induced paw licking tests. Oral administration of MPEE produced significant dose-dependent antinociceptive effects when tested in mice and rats using acetic acid-induced abdominal constriction test and on the second phase of the formalin-induced paw licking test, respectively. It was also demonstrated that MPEE had no effect on the response latency time to the heat stimulus in the thermal model of the hot-plate test. In addition, the antinociception produced by MPEE was not blocked by naloxone. Furthermore, oral administration of MPEE did not produce any effect in motor performance of the rota-rod test and in acute toxicity study no abnormal behaviors as well as mortality were observed up to a dose level of the extract of 5 g/kg. These results indicated that MPEE at all doses investigated which did not produce any sedative and toxic effects exerted pronounce antinociceptive activity that acts peripherally in experimental animals.
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spelling pubmed-30222152011-01-27 Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals Sulaiman, Mohd Roslan Mohd Padzil, Azyyati Shaari, Khozirah Khalid, Syamimi Shaik Mossadeq, Wan Mastura Mohamad, Azam Shah Ahmad, Syahida Akira, Ahmad Israf, Daud Lajis, Nordin J Biomed Biotechnol Research Article Melicope ptelefolia is a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches. The present study was conducted to evaluate the antinociceptive activity of the Melicope ptelefolia ethanolic extract (MPEE) using animal models of nociception. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin-induced paw licking tests. Oral administration of MPEE produced significant dose-dependent antinociceptive effects when tested in mice and rats using acetic acid-induced abdominal constriction test and on the second phase of the formalin-induced paw licking test, respectively. It was also demonstrated that MPEE had no effect on the response latency time to the heat stimulus in the thermal model of the hot-plate test. In addition, the antinociception produced by MPEE was not blocked by naloxone. Furthermore, oral administration of MPEE did not produce any effect in motor performance of the rota-rod test and in acute toxicity study no abnormal behaviors as well as mortality were observed up to a dose level of the extract of 5 g/kg. These results indicated that MPEE at all doses investigated which did not produce any sedative and toxic effects exerted pronounce antinociceptive activity that acts peripherally in experimental animals. Hindawi Publishing Corporation 2010 2011-01-02 /pmc/articles/PMC3022215/ /pubmed/21274262 http://dx.doi.org/10.1155/2010/937642 Text en Copyright © 2010 Mohd Roslan Sulaiman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sulaiman, Mohd Roslan
Mohd Padzil, Azyyati
Shaari, Khozirah
Khalid, Syamimi
Shaik Mossadeq, Wan Mastura
Mohamad, Azam Shah
Ahmad, Syahida
Akira, Ahmad
Israf, Daud
Lajis, Nordin
Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals
title Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals
title_full Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals
title_fullStr Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals
title_full_unstemmed Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals
title_short Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals
title_sort antinociceptive activity of melicope ptelefolia ethanolic extract in experimental animals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022215/
https://www.ncbi.nlm.nih.gov/pubmed/21274262
http://dx.doi.org/10.1155/2010/937642
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