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Metabolomic Profiling for Identification of Novel Potential Biomarkers in Cardiovascular Diseases

Metabolomics involves the identification and quantification of metabolites present in a biological system. Three different approaches can be used: metabolomic fingerprinting, metabolic profiling, and metabolic footprinting, in order to evaluate the clinical course of a disease, patient recovery, cha...

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Detalles Bibliográficos
Autores principales: Barderas, Maria G., Laborde, Carlos M., Posada, Maria, de la Cuesta, Fernando, Zubiri, Irene, Vivanco, Fernando, Alvarez-Llamas, Gloria
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022229/
https://www.ncbi.nlm.nih.gov/pubmed/21274272
http://dx.doi.org/10.1155/2011/790132
Descripción
Sumario:Metabolomics involves the identification and quantification of metabolites present in a biological system. Three different approaches can be used: metabolomic fingerprinting, metabolic profiling, and metabolic footprinting, in order to evaluate the clinical course of a disease, patient recovery, changes in response to surgical intervention or pharmacological treatment, as well as other associated features. Characteristic patterns of metabolites can be revealed that broaden our understanding of a particular disorder. In the present paper, common strategies and analytical techniques used in metabolomic studies are reviewed, particularly with reference to the cardiovascular field.