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Atherosclerosis and Thrombosis: Insights from Large Animal Models
Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. The combination of in vitro, ex vivo, and in vivo experimental approaches has largely contributed to a better understanding of the mechanisms underlying the atherothrombotic process. Indeed, diffe...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022266/ https://www.ncbi.nlm.nih.gov/pubmed/21274431 http://dx.doi.org/10.1155/2011/907575 |
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author | Vilahur, Gemma Padro, Teresa Badimon, Lina |
author_facet | Vilahur, Gemma Padro, Teresa Badimon, Lina |
author_sort | Vilahur, Gemma |
collection | PubMed |
description | Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. The combination of in vitro, ex vivo, and in vivo experimental approaches has largely contributed to a better understanding of the mechanisms underlying the atherothrombotic process. Indeed, different animal models have been implemented in atherosclerosis and thrombosis research in order to provide new insights into the mechanisms that have already been outlined in isolated cells and protein studies. Yet, although no model completely mimics the human pathology, large animal models have demonstrated better suitability for translation to humans. Indeed, direct translation from mice to humans should be taken with caution because of the well-reported species-related differences. This paper provides an overview of the available atherothrombotic-like animal models, with a particular focus on large animal models of thrombosis and atherosclerosis, and examines their applicability for translational research purposes as well as highlights species-related differences with humans. |
format | Text |
id | pubmed-3022266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30222662011-01-27 Atherosclerosis and Thrombosis: Insights from Large Animal Models Vilahur, Gemma Padro, Teresa Badimon, Lina J Biomed Biotechnol Review Article Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. The combination of in vitro, ex vivo, and in vivo experimental approaches has largely contributed to a better understanding of the mechanisms underlying the atherothrombotic process. Indeed, different animal models have been implemented in atherosclerosis and thrombosis research in order to provide new insights into the mechanisms that have already been outlined in isolated cells and protein studies. Yet, although no model completely mimics the human pathology, large animal models have demonstrated better suitability for translation to humans. Indeed, direct translation from mice to humans should be taken with caution because of the well-reported species-related differences. This paper provides an overview of the available atherothrombotic-like animal models, with a particular focus on large animal models of thrombosis and atherosclerosis, and examines their applicability for translational research purposes as well as highlights species-related differences with humans. Hindawi Publishing Corporation 2011 2011-01-02 /pmc/articles/PMC3022266/ /pubmed/21274431 http://dx.doi.org/10.1155/2011/907575 Text en Copyright © 2011 Gemma Vilahur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Vilahur, Gemma Padro, Teresa Badimon, Lina Atherosclerosis and Thrombosis: Insights from Large Animal Models |
title | Atherosclerosis and Thrombosis: Insights from Large Animal Models |
title_full | Atherosclerosis and Thrombosis: Insights from Large Animal Models |
title_fullStr | Atherosclerosis and Thrombosis: Insights from Large Animal Models |
title_full_unstemmed | Atherosclerosis and Thrombosis: Insights from Large Animal Models |
title_short | Atherosclerosis and Thrombosis: Insights from Large Animal Models |
title_sort | atherosclerosis and thrombosis: insights from large animal models |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022266/ https://www.ncbi.nlm.nih.gov/pubmed/21274431 http://dx.doi.org/10.1155/2011/907575 |
work_keys_str_mv | AT vilahurgemma atherosclerosisandthrombosisinsightsfromlargeanimalmodels AT padroteresa atherosclerosisandthrombosisinsightsfromlargeanimalmodels AT badimonlina atherosclerosisandthrombosisinsightsfromlargeanimalmodels |