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Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population

OBJECTIVE: Associations of thyroid dysfunction with cognitive impairment and depression in late-life have been described but remain controversial. This study aimed to investigate the associations of serum thyroid stimulating hormone (TSH) levels with cognitive impairment and depression after control...

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Autores principales: Kim, Jae-Min, Stewart, Robert, Kim, Seon-Young, Bae, Kyung-Yeol, Yang, Su-Jin, Kim, Sung-Wan, Shin, Il-Seon, Yoon, Jin-Sang
Formato: Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022313/
https://www.ncbi.nlm.nih.gov/pubmed/21253410
http://dx.doi.org/10.4306/pi.2010.7.4.264
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author Kim, Jae-Min
Stewart, Robert
Kim, Seon-Young
Bae, Kyung-Yeol
Yang, Su-Jin
Kim, Sung-Wan
Shin, Il-Seon
Yoon, Jin-Sang
author_facet Kim, Jae-Min
Stewart, Robert
Kim, Seon-Young
Bae, Kyung-Yeol
Yang, Su-Jin
Kim, Sung-Wan
Shin, Il-Seon
Yoon, Jin-Sang
author_sort Kim, Jae-Min
collection PubMed
description OBJECTIVE: Associations of thyroid dysfunction with cognitive impairment and depression in late-life have been described but remain controversial. This study aimed to investigate the associations of serum thyroid stimulating hormone (TSH) levels with cognitive impairment and depression after controlling for potential confounding factors. METHODS: The sample consisted of 495 community residents aged 65 or over in whom serum TSH had been assayed. Cognitive impairment was defined using the Community Screening Interview for Dementia, and depression was diagnosed using the Geriatric Mental State schedule. Age, gender, education, smoking history, physical activity, blood pressure, diabetes, and serum total cholesterol and albumin were included as covariates. RESULTS: There was a significant association between lower (hyperthyroid) serum TSH levels (<0.5 mIU/L) and cognitive impairment after adjustment [odds ratio 7.12 (95% confidence interval 1.35-37.5)]. However, no association was found between TSH levels and depression. CONCLUSION: Based on TSH levels, hyperthyroidism but not hypothyroidism was associated with cognitive impairment in this sample, and we found no evidence for an association of either with depression.
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spelling pubmed-30223132011-01-20 Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population Kim, Jae-Min Stewart, Robert Kim, Seon-Young Bae, Kyung-Yeol Yang, Su-Jin Kim, Sung-Wan Shin, Il-Seon Yoon, Jin-Sang Psychiatry Investig Original Article OBJECTIVE: Associations of thyroid dysfunction with cognitive impairment and depression in late-life have been described but remain controversial. This study aimed to investigate the associations of serum thyroid stimulating hormone (TSH) levels with cognitive impairment and depression after controlling for potential confounding factors. METHODS: The sample consisted of 495 community residents aged 65 or over in whom serum TSH had been assayed. Cognitive impairment was defined using the Community Screening Interview for Dementia, and depression was diagnosed using the Geriatric Mental State schedule. Age, gender, education, smoking history, physical activity, blood pressure, diabetes, and serum total cholesterol and albumin were included as covariates. RESULTS: There was a significant association between lower (hyperthyroid) serum TSH levels (<0.5 mIU/L) and cognitive impairment after adjustment [odds ratio 7.12 (95% confidence interval 1.35-37.5)]. However, no association was found between TSH levels and depression. CONCLUSION: Based on TSH levels, hyperthyroidism but not hypothyroidism was associated with cognitive impairment in this sample, and we found no evidence for an association of either with depression. Korean Neuropsychiatric Association 2010-12 2010-11-30 /pmc/articles/PMC3022313/ /pubmed/21253410 http://dx.doi.org/10.4306/pi.2010.7.4.264 Text en Copyright © 2010 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jae-Min
Stewart, Robert
Kim, Seon-Young
Bae, Kyung-Yeol
Yang, Su-Jin
Kim, Sung-Wan
Shin, Il-Seon
Yoon, Jin-Sang
Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population
title Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population
title_full Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population
title_fullStr Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population
title_full_unstemmed Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population
title_short Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population
title_sort thyroid stimulating hormone, cognitive impairment and depression in an older korean population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022313/
https://www.ncbi.nlm.nih.gov/pubmed/21253410
http://dx.doi.org/10.4306/pi.2010.7.4.264
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