GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses

Gene associated with retinoid-interferon-β-induced mortality (GRIM)—19, was originally identified as a critical regulatory protein necessary for Interferon-β-Retinoic acid-induced cell death. Overexpression of GRIM-19 activates cell death and its suppression or inactivation promotes cell growth. GRI...

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Autores principales: Nallar, Shreeram C., Kalakonda, Sudhakar, Sun, Peng, Kalvakolanu, Dhan V.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022361/
https://www.ncbi.nlm.nih.gov/pubmed/21566745
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author Nallar, Shreeram C.
Kalakonda, Sudhakar
Sun, Peng
Kalvakolanu, Dhan V.
author_facet Nallar, Shreeram C.
Kalakonda, Sudhakar
Sun, Peng
Kalvakolanu, Dhan V.
author_sort Nallar, Shreeram C.
collection PubMed
description Gene associated with retinoid-interferon-β-induced mortality (GRIM)—19, was originally identified as a critical regulatory protein necessary for Interferon-β-Retinoic acid-induced cell death. Overexpression of GRIM-19 activates cell death and its suppression or inactivation promotes cell growth. GRIM-19 targets multiple proteins/pathways for exerting growth control and cell death. However, GRIM-19 is also required for normal cellular processes. In addition, viruses ‘hijack’ GRIM-19 for their survival. Intracellular bacterial infections and bacterial products have been reported to induce the expression of GRIM-19. In this review, we will discuss the current status of GRIM-19 in growth control and innate immune response.
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spelling pubmed-30223612011-05-12 GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses Nallar, Shreeram C. Kalakonda, Sudhakar Sun, Peng Kalvakolanu, Dhan V. Transl Oncogenomics Original Research Gene associated with retinoid-interferon-β-induced mortality (GRIM)—19, was originally identified as a critical regulatory protein necessary for Interferon-β-Retinoic acid-induced cell death. Overexpression of GRIM-19 activates cell death and its suppression or inactivation promotes cell growth. GRIM-19 targets multiple proteins/pathways for exerting growth control and cell death. However, GRIM-19 is also required for normal cellular processes. In addition, viruses ‘hijack’ GRIM-19 for their survival. Intracellular bacterial infections and bacterial products have been reported to induce the expression of GRIM-19. In this review, we will discuss the current status of GRIM-19 in growth control and innate immune response. Libertas Academica 2008-03-17 /pmc/articles/PMC3022361/ /pubmed/21566745 Text en © 2008 The authors. http://creativecommons.org/licenses/by/3.0 This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0. (http://creativecommons.org/licenses/by/3.0)
spellingShingle Original Research
Nallar, Shreeram C.
Kalakonda, Sudhakar
Sun, Peng
Kalvakolanu, Dhan V.
GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses
title GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses
title_full GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses
title_fullStr GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses
title_full_unstemmed GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses
title_short GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses
title_sort grim-19: a double-edged sword that regulates anti-tumor and innate immune responses
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022361/
https://www.ncbi.nlm.nih.gov/pubmed/21566745
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AT sunpeng grim19adoubleedgedswordthatregulatesantitumorandinnateimmuneresponses
AT kalvakolanudhanv grim19adoubleedgedswordthatregulatesantitumorandinnateimmuneresponses

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