Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common.

Detalles Bibliográficos
Autores principales: Anderson, Carl A., Soranzo, Nicole, Zeggini, Eleftheria, Barrett, Jeffrey C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022527/
https://www.ncbi.nlm.nih.gov/pubmed/21267062
http://dx.doi.org/10.1371/journal.pbio.1000580
Descripción
Sumario:Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common.

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