Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common.

Detalles Bibliográficos
Autores principales: Anderson, Carl A., Soranzo, Nicole, Zeggini, Eleftheria, Barrett, Jeffrey C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022527/
https://www.ncbi.nlm.nih.gov/pubmed/21267062
http://dx.doi.org/10.1371/journal.pbio.1000580
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author Anderson, Carl A.
Soranzo, Nicole
Zeggini, Eleftheria
Barrett, Jeffrey C.
author_facet Anderson, Carl A.
Soranzo, Nicole
Zeggini, Eleftheria
Barrett, Jeffrey C.
author_sort Anderson, Carl A.
collection PubMed
description Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common.
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spelling pubmed-30225272011-01-25 Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals Anderson, Carl A. Soranzo, Nicole Zeggini, Eleftheria Barrett, Jeffrey C. PLoS Biol Perspective Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common. Public Library of Science 2011-01-18 /pmc/articles/PMC3022527/ /pubmed/21267062 http://dx.doi.org/10.1371/journal.pbio.1000580 Text en Anderson et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Perspective
Anderson, Carl A.
Soranzo, Nicole
Zeggini, Eleftheria
Barrett, Jeffrey C.
Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
title Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
title_full Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
title_fullStr Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
title_full_unstemmed Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
title_short Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
title_sort synthetic associations are unlikely to account for many common disease genome-wide association signals
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022527/
https://www.ncbi.nlm.nih.gov/pubmed/21267062
http://dx.doi.org/10.1371/journal.pbio.1000580
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