Cargando…

Eag and HERG potassium channels as novel therapeutic targets in cancer

Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential therapeutic utility in the treatment of cancer. Eag a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Asher, Viren, Sowter, Heidi, Shaw, Robert, Bali, Anish, Khan, Raheela
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022597/ https://www.ncbi.nlm.nih.gov/pubmed/21190577 http://dx.doi.org/10.1186/1477-7819-8-113

Ejemplares similares

The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line
por: Asher, Viren, et al.
Publicado: (2011)

The Eag potassium channel as a new prognostic marker in ovarian cancer
por: Asher, Viren, et al.
Publicado: (2010)

Overexpression of Eag1 potassium channels in clinical tumours
por: Hemmerlein, Bernhard, et al.
Publicado: (2006)

The eag domain regulates hERG channel inactivation gating via a direct interaction
por: Gustina, Ahleah S., et al.
Publicado: (2013)

Crystal structure of the PAS domain of the hEAG potassium channel
por: Tang, Xue, et al.
Publicado: (2016)

The mechanism study of Eag1 potassium channel in gastric cancer
por: Gao, Shan, et al.
Publicado: (2022)

Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels
por: Gianulis, Elena C., et al.
Publicado: (2013)

Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Liu, Qiang-ni, et al.
Publicado: (2015)

Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth
por: Francisco, Michelle A., et al.
Publicado: (2020)

Stereoselective Inhibition of the hERG1 Potassium Channel
por: Grilo, Liliana Sintra, et al.
Publicado: (2010)

Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin
por: Duncan, R.S., et al.
Publicado: (2007)

Na(+) Permeation and Block of hERG Potassium Channels
por: Gang, Hongying, et al.
Publicado: (2006)

Voltage-Dependent Gating of hERG Potassium Channels
por: Cheng, Yen May, et al.
Publicado: (2012)

Ion Conduction through the hERG Potassium Channel
por: Ceccarini, Luisa, et al.
Publicado: (2012)

hERG1a N-terminal eag domain–containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: A possible mechanism for long QT syndrome
por: Trudeau, Matthew C., et al.
Publicado: (2011)

Suppression of the Eag1 potassium channel sensitizes glioblastoma cells to injury caused by temozolomide
por: Sales, Thais Torquato, et al.
Publicado: (2016)

Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels
por: Hsu, Po-Hao, et al.
Publicado: (2017)

hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers
por: Lastraioli, Elena, et al.
Publicado: (2015)

The Eag Domain Regulates the Voltage-Dependent Inactivation of Rat Eag1 K(+) Channels
por: Lin, Ting-Feng, et al.
Publicado: (2014)

Fast and Slow Voltage Sensor Movements in HERG Potassium Channels
por: Smith, Paula L., et al.
Publicado: (2002)

Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism
por: Frolov, Roman V., et al.
Publicado: (2011)

Mechanism of C-type inactivation in the hERG potassium channel
por: Li, Jing, et al.
Publicado: (2021)

Flavonoid regulation of EAG1 channels
por: Carlson, Anne E., et al.
Publicado: (2013)

14-3-3θ is a Binding Partner of Rat Eag1 Potassium Channels
por: Hsu, Po-Hao, et al.
Publicado: (2012)

Regulation of hERG and hEAG Channels by Src and by SHP-1 Tyrosine Phosphatase via an ITIM Region in the Cyclic Nucleotide Binding Domain
por: Schlichter, Lyanne C., et al.
Publicado: (2014)

The N-linker region of hERG1a upregulates hERG1b potassium channels
por: Johnson, Ashley A., et al.
Publicado: (2022)

Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate
por: Mitcheson, John S., et al.
Publicado: (2000)

The Basis for Low-affinity hERG Potassium Channel Block by Sotalol
por: Zhang, Yi Hong, et al.
Publicado: (2017)

Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
por: Zhang, Xiaomeng, et al.
Publicado: (2019)

Structural modeling of the hERG potassium channel and associated drug interactions
por: Maly, Jan, et al.
Publicado: (2022)

Early Steps in C-Type Inactivation of the hERG Potassium Channel
por: Pettini, Francesco, et al.
Publicado: (2022)

Noncanonical electromechanical coupling paths in cardiac hERG potassium channel
por: Bassetto, Carlos A. Z., et al.
Publicado: (2023)

Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain
por: Lörinczi, Eva, et al.
Publicado: (2016)

Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration
por: Melgari, Dario, et al.
Publicado: (2014)

Eag1 Channels as Potential Cancer Biomarkers
por: Rodríguez-Rasgado, Jesús Adrián, et al.
Publicado: (2012)

hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine
por: Melgari, Dario, et al.
Publicado: (2015)

Electrophysiological characterization of the modified hERG(T) potassium channel used to obtain the first cryo‐EM hERG structure
por: Zhang, Yihong, et al.
Publicado: (2020)

κO-SrVIA Conopeptide, a Novel Inhibitor Peptide for Two Members of the Human EAG Potassium Channel Family
por: Martínez-Hernández, Luis, et al.
Publicado: (2023)

Mechanistic Insight into Human ether-à-go-go-related Gene (hERG) K(+) Channel Deactivation Gating from the Solution Structure of the EAG Domain
por: Muskett, Frederick W., et al.
Publicado: (2011)

Structural and Functional Role of the Extracellular S5-P Linker in the HERG Potassium Channel
por: Liu, Jie, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_178p91p2elke5jimesb2npqhjv