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Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit

BACKGROUND: The voltage-gated sodium channel β2 subunit (Navβ2) is a physiological substrate of BACE1 (β-site APP cleaving enzyme) and γ-secretase, two proteolytic enzymes central to Alzheimer's disease pathogenesis. Previously, we have found that the processing of Navβ2 by BACE1 and γ-secretas...

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Detalles Bibliográficos
Autores principales:	Gersbacher, Manuel T, Kim, Doo Yeon, Bhattacharyya, Raja, Kovacs, Dora M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022600/ https://www.ncbi.nlm.nih.gov/pubmed/21182789 http://dx.doi.org/10.1186/1750-1326-5-61

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