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Perifosine and CCI 779 Co-Operate to Induce Cell Death and Decrease Proliferation in PTEN-Intact and PTEN-Deficient PDGF-Driven Murine Glioblastoma

BACKGROUND: Platelet derived growth factor receptor (PDGFR) activity is deregulated in human GBM due to amplification and rearrangement of the PDGFR-alpha gene locus or overexpression of the PDGF ligand, resulting in the activation of downstream kinases such as phosphatidylinositol 3-kinase (PI3K),...

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Detalles Bibliográficos
Autores principales:	Pitter, Kenneth L., Galbán, Craig J., Galbán, Stefanie, Saeed-Tehrani, Omid, Li, Fei, Charles, Nikki, Bradbury, Michelle S., Becher, Oren J., Chenevert, Thomas L., Rehemtulla, Alnawaz, Ross, Brian D., Holland, Eric C., Hambardzumyan, Dolores
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022633/ https://www.ncbi.nlm.nih.gov/pubmed/21267448 http://dx.doi.org/10.1371/journal.pone.0014545

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