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Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27(kip1 )in rats

BACKGROUND: Pulmonary vascular structure remodeling (PVSR) is a hallmark of pulmonary hypertension. P27(kip1), one of critical cyclin-dependent kinase inhibitors, has been shown to mediate anti-proliferation effects on various vascular cells. Beta-estradiol (β-E2) has numerous biological protective...

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Detalles Bibliográficos
Autores principales:	Xu, Dun-Quan, Luo, Ying, Liu, Yi, Wang, Jing, Zhang, Bo, Xu, Min, Wang, Yan-Xia, Dong, Hai-Ying, Dong, Ming-Qing, Zhao, Peng-Tao, Niu, Wen, Liu, Man-Ling, Gao, Yu-Qi, Li, Zhi-Chao
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022723/ https://www.ncbi.nlm.nih.gov/pubmed/21182801 http://dx.doi.org/10.1186/1465-9921-11-182

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