A New Approach for Heparin Standardization: Combination of Scanning UV Spectroscopy, Nuclear Magnetic Resonance and Principal Component Analysis

The year 2007 was marked by widespread adverse clinical responses to heparin use, leading to a global recall of potentially affected heparin batches in 2008. Several analytical methods have since been developed to detect impurities in heparin preparations; however, many are costly and dependent on i...

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Detalles Bibliográficos
Autores principales: Lima, Marcelo A., Rudd, Timothy R., de Farias, Eduardo H. C., Ebner, Lyvia F., Gesteira, Tarsis F., de Souza, Lauro M., Mendes, Aline, Córdula, Carolina R., Martins, João R. M., Hoppensteadt, Debra, Fareed, Jawed, Sassaki, Guilherme L., Yates, Edwin A., Tersariol, Ivarne L. S., Nader, Helena B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022730/
https://www.ncbi.nlm.nih.gov/pubmed/21267460
http://dx.doi.org/10.1371/journal.pone.0015970

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