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All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment

BACKGROUND: Preterm birth is the leading cause of perinatal morbidity and mortality. Risk factors for preterm birth include a personal or familial history of preterm delivery, ethnicity and low socioeconomic status yet the ability to predict preterm delivery before the onset of preterm labour evades...

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Autores principales: Gracie, Sara K, Lyon, Andrew W, Kehler, Heather L, Pennell, Craig E, Dolan, Siobhan M, McNeil, Deborah A, Siever, Jodi E, McDonald, Sheila W, Bocking, Alan D, Lye, Stephen J, Hegadoren, Kathy M, Olson, David M, Tough, Suzanne C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022739/
https://www.ncbi.nlm.nih.gov/pubmed/21192811
http://dx.doi.org/10.1186/1471-2393-10-87
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author Gracie, Sara K
Lyon, Andrew W
Kehler, Heather L
Pennell, Craig E
Dolan, Siobhan M
McNeil, Deborah A
Siever, Jodi E
McDonald, Sheila W
Bocking, Alan D
Lye, Stephen J
Hegadoren, Kathy M
Olson, David M
Tough, Suzanne C
author_facet Gracie, Sara K
Lyon, Andrew W
Kehler, Heather L
Pennell, Craig E
Dolan, Siobhan M
McNeil, Deborah A
Siever, Jodi E
McDonald, Sheila W
Bocking, Alan D
Lye, Stephen J
Hegadoren, Kathy M
Olson, David M
Tough, Suzanne C
author_sort Gracie, Sara K
collection PubMed
description BACKGROUND: Preterm birth is the leading cause of perinatal morbidity and mortality. Risk factors for preterm birth include a personal or familial history of preterm delivery, ethnicity and low socioeconomic status yet the ability to predict preterm delivery before the onset of preterm labour evades clinical practice. Evidence suggests that genetics may play a role in the multi-factorial pathophysiology of preterm birth. The All Our Babies Study is an on-going community based longitudinal cohort study that was designed to establish a cohort of women to investigate how a women's genetics and environment contribute to the pathophysiology of preterm birth. Specifically this study will examine the predictive potential of maternal leukocytes for predicting preterm birth in non-labouring women through the examination of gene expression profiles and gene-environment interactions. METHODS/DESIGN: Collaborations have been established between clinical lab services, the provincial health service provider and researchers to create an interdisciplinary study design for the All Our Babies Study. A birth cohort of 2000 women has been established to address this research question. Women provide informed consent for blood sample collection, linkage to medical records and complete questionnaires related to prenatal health, service utilization, social support, emotional and physical health, demographics, and breast and infant feeding. Maternal blood samples are collected in PAXgene™ RNA tubes between 18-22 and 28-32 weeks gestation for transcriptomic analyses. DISCUSSION: The All Our Babies Study is an example of how investment in clinical-academic-community partnerships can improve research efficiency and accelerate the recruitment and data collection phases of a study. Establishing these partnerships during the study design phase and maintaining these relationships through the duration of the study provides the unique opportunity to investigate the multi-causal factors of preterm birth. The overall All Our Babies Study results can potentially lead to healthier pregnancies, mothers, infants and children.
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spelling pubmed-30227392011-01-19 All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment Gracie, Sara K Lyon, Andrew W Kehler, Heather L Pennell, Craig E Dolan, Siobhan M McNeil, Deborah A Siever, Jodi E McDonald, Sheila W Bocking, Alan D Lye, Stephen J Hegadoren, Kathy M Olson, David M Tough, Suzanne C BMC Pregnancy Childbirth Study Protocol BACKGROUND: Preterm birth is the leading cause of perinatal morbidity and mortality. Risk factors for preterm birth include a personal or familial history of preterm delivery, ethnicity and low socioeconomic status yet the ability to predict preterm delivery before the onset of preterm labour evades clinical practice. Evidence suggests that genetics may play a role in the multi-factorial pathophysiology of preterm birth. The All Our Babies Study is an on-going community based longitudinal cohort study that was designed to establish a cohort of women to investigate how a women's genetics and environment contribute to the pathophysiology of preterm birth. Specifically this study will examine the predictive potential of maternal leukocytes for predicting preterm birth in non-labouring women through the examination of gene expression profiles and gene-environment interactions. METHODS/DESIGN: Collaborations have been established between clinical lab services, the provincial health service provider and researchers to create an interdisciplinary study design for the All Our Babies Study. A birth cohort of 2000 women has been established to address this research question. Women provide informed consent for blood sample collection, linkage to medical records and complete questionnaires related to prenatal health, service utilization, social support, emotional and physical health, demographics, and breast and infant feeding. Maternal blood samples are collected in PAXgene™ RNA tubes between 18-22 and 28-32 weeks gestation for transcriptomic analyses. DISCUSSION: The All Our Babies Study is an example of how investment in clinical-academic-community partnerships can improve research efficiency and accelerate the recruitment and data collection phases of a study. Establishing these partnerships during the study design phase and maintaining these relationships through the duration of the study provides the unique opportunity to investigate the multi-causal factors of preterm birth. The overall All Our Babies Study results can potentially lead to healthier pregnancies, mothers, infants and children. BioMed Central 2010-12-30 /pmc/articles/PMC3022739/ /pubmed/21192811 http://dx.doi.org/10.1186/1471-2393-10-87 Text en Copyright ©2010 Gracie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Protocol
Gracie, Sara K
Lyon, Andrew W
Kehler, Heather L
Pennell, Craig E
Dolan, Siobhan M
McNeil, Deborah A
Siever, Jodi E
McDonald, Sheila W
Bocking, Alan D
Lye, Stephen J
Hegadoren, Kathy M
Olson, David M
Tough, Suzanne C
All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment
title All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment
title_full All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment
title_fullStr All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment
title_full_unstemmed All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment
title_short All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment
title_sort all our babies cohort study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022739/
https://www.ncbi.nlm.nih.gov/pubmed/21192811
http://dx.doi.org/10.1186/1471-2393-10-87
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