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Right coronary wall cmr in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium
BACKGROUND: Coronary wall cardiovascular magnetic resonance (CMR) is a promising noninvasive approach to assess subclinical atherosclerosis, but data are limited in subjects over 60 years old, who are at increased risk. The purpose of the study was to evaluate coronary wall CMR in an asymptomatic ol...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022803/ https://www.ncbi.nlm.nih.gov/pubmed/21192815 http://dx.doi.org/10.1186/1532-429X-12-75 |
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author | Terashima, Masahiro Nguyen, Patricia K Rubin, Geoffrey D Meyer, Craig H Shimakawa, Ann Nishimura, Dwight G Ehara, Shoichi Iribarren, Carlos Courtney, Brian K Go, Alan S Hlatky, Mark A Fortmann, Stephen P McConnell, Michael V |
author_facet | Terashima, Masahiro Nguyen, Patricia K Rubin, Geoffrey D Meyer, Craig H Shimakawa, Ann Nishimura, Dwight G Ehara, Shoichi Iribarren, Carlos Courtney, Brian K Go, Alan S Hlatky, Mark A Fortmann, Stephen P McConnell, Michael V |
author_sort | Terashima, Masahiro |
collection | PubMed |
description | BACKGROUND: Coronary wall cardiovascular magnetic resonance (CMR) is a promising noninvasive approach to assess subclinical atherosclerosis, but data are limited in subjects over 60 years old, who are at increased risk. The purpose of the study was to evaluate coronary wall CMR in an asymptomatic older cohort. RESULTS: Cross-sectional images of the proximal right coronary artery (RCA) were acquired using spiral black-blood coronary CMR (0.7 mm resolution) in 223 older, community-based patients without a history of cardiovascular disease (age 60-72 years old, 38% female). Coronary measurements (total vessel area, lumen area, wall area, and wall thickness) had small intra- and inter-observer variabilities (r = 0.93~0.99, all p < 0.0001), though one-third of these older subjects had suboptimal image quality. Increased coronary wall thickness correlated with increased coronary vessel area (p < 0.0001), consistent with positive remodeling. On multivariate analysis, type 2 diabetes was the only risk factor associated with increased coronary wall area and thickness (p = 0.03 and p = 0.007, respectively). Coronary wall CMR measures were also associated with coronary calcification (p = 0.01-0.03). CONCLUSIONS: Right coronary wall CMR in asymptomatic older subjects showed increased coronary atherosclerosis in subjects with type 2 diabetes as well as coronary calcification. Coronary wall CMR may contribute to the noninvasive assessment of subclinical coronary atherosclerosis in older, at-risk patient groups. |
format | Text |
id | pubmed-3022803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30228032011-01-19 Right coronary wall cmr in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium Terashima, Masahiro Nguyen, Patricia K Rubin, Geoffrey D Meyer, Craig H Shimakawa, Ann Nishimura, Dwight G Ehara, Shoichi Iribarren, Carlos Courtney, Brian K Go, Alan S Hlatky, Mark A Fortmann, Stephen P McConnell, Michael V J Cardiovasc Magn Reson Research BACKGROUND: Coronary wall cardiovascular magnetic resonance (CMR) is a promising noninvasive approach to assess subclinical atherosclerosis, but data are limited in subjects over 60 years old, who are at increased risk. The purpose of the study was to evaluate coronary wall CMR in an asymptomatic older cohort. RESULTS: Cross-sectional images of the proximal right coronary artery (RCA) were acquired using spiral black-blood coronary CMR (0.7 mm resolution) in 223 older, community-based patients without a history of cardiovascular disease (age 60-72 years old, 38% female). Coronary measurements (total vessel area, lumen area, wall area, and wall thickness) had small intra- and inter-observer variabilities (r = 0.93~0.99, all p < 0.0001), though one-third of these older subjects had suboptimal image quality. Increased coronary wall thickness correlated with increased coronary vessel area (p < 0.0001), consistent with positive remodeling. On multivariate analysis, type 2 diabetes was the only risk factor associated with increased coronary wall area and thickness (p = 0.03 and p = 0.007, respectively). Coronary wall CMR measures were also associated with coronary calcification (p = 0.01-0.03). CONCLUSIONS: Right coronary wall CMR in asymptomatic older subjects showed increased coronary atherosclerosis in subjects with type 2 diabetes as well as coronary calcification. Coronary wall CMR may contribute to the noninvasive assessment of subclinical coronary atherosclerosis in older, at-risk patient groups. BioMed Central 2010-12-30 /pmc/articles/PMC3022803/ /pubmed/21192815 http://dx.doi.org/10.1186/1532-429X-12-75 Text en Copyright ©2010 Terashima et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Terashima, Masahiro Nguyen, Patricia K Rubin, Geoffrey D Meyer, Craig H Shimakawa, Ann Nishimura, Dwight G Ehara, Shoichi Iribarren, Carlos Courtney, Brian K Go, Alan S Hlatky, Mark A Fortmann, Stephen P McConnell, Michael V Right coronary wall cmr in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium |
title | Right coronary wall cmr in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium |
title_full | Right coronary wall cmr in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium |
title_fullStr | Right coronary wall cmr in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium |
title_full_unstemmed | Right coronary wall cmr in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium |
title_short | Right coronary wall cmr in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium |
title_sort | right coronary wall cmr in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022803/ https://www.ncbi.nlm.nih.gov/pubmed/21192815 http://dx.doi.org/10.1186/1532-429X-12-75 |
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