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Impact of Dedicated Brain PET on Intended Patient Management in Participants of the National Oncologic PET Registry

PURPOSE: This study seeks to assess the impact of dedicated brain positron emission tomography (PET) with 2-deoxy-2-[(18)F]fluoro-d-glucose on intended management of patients with primary and metastatic brain tumors. PROCEDURES: We analyzed demographic characteristics and evaluated change in intende...

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Autores principales: Hillner, Bruce E., Siegel, Barry A., Shields, Anthony F., Duan, Fenghai, Gareen, Ilana F., Hanna, Lucy, Coleman, R. Edward
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023024/
https://www.ncbi.nlm.nih.gov/pubmed/21080232
http://dx.doi.org/10.1007/s11307-010-0427-5
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author Hillner, Bruce E.
Siegel, Barry A.
Shields, Anthony F.
Duan, Fenghai
Gareen, Ilana F.
Hanna, Lucy
Coleman, R. Edward
author_facet Hillner, Bruce E.
Siegel, Barry A.
Shields, Anthony F.
Duan, Fenghai
Gareen, Ilana F.
Hanna, Lucy
Coleman, R. Edward
author_sort Hillner, Bruce E.
collection PubMed
description PURPOSE: This study seeks to assess the impact of dedicated brain positron emission tomography (PET) with 2-deoxy-2-[(18)F]fluoro-d-glucose on intended management of patients with primary and metastatic brain tumors. PROCEDURES: We analyzed demographic characteristics and evaluated change in intended management after PET, using previously described metrics, for patients in the National Oncologic PET Registry (NOPR) undergoing dedicated brain PET. For cases of primary brain tumors, comparisons to the overall NOPR cohort were made. PATIENT PROFILE: Between December 2006 and April 2009, 509 dedicated brain PET scans were done on 479 patients—367 (72.1%) for suspected or proven primary brain tumors and 142 (27.9%) for brain metastases. Compared with the overall NOPR cohort, subjects in the dedicated brain cohort were younger (41.3% less than 65 years vs. 10.5% overall, p < 0.0001) and more frequently had functional limitations from their cancers (78.6% vs. 62.3% overall; odds ratio (OR) 2.2, 95% CI 1.8–2.8). RESULTS: The pre-PET patient management plans in the primary brain tumor and metastasis subgroups were similar. A pre-PET plan of tissue biopsy was slightly more frequent than one of the treatments (31.3% vs. 28.6%) in the primary brain tumor subgroup and was more common than in the overall NOPR cohort (14.2%; OR 2.8, 95% CI 2.2–3.5). Changes from treatment to non-treatment also were more frequent than in the overall NOPR cohort (13.4% vs. 7.7%; OR 1.9, 95% CI 1.3–2.5). CONCLUSIONS: Among NOPR patients, dedicated brain PET was associated with similar net changes in intended management as in the overall NOPR cohort. However, brain PET patients were younger, more likely to be symptomatic, and less likely to have a change in management from non-treatment to treatment as a post-PET plan.
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spelling pubmed-30230242011-02-22 Impact of Dedicated Brain PET on Intended Patient Management in Participants of the National Oncologic PET Registry Hillner, Bruce E. Siegel, Barry A. Shields, Anthony F. Duan, Fenghai Gareen, Ilana F. Hanna, Lucy Coleman, R. Edward Mol Imaging Biol Research Article PURPOSE: This study seeks to assess the impact of dedicated brain positron emission tomography (PET) with 2-deoxy-2-[(18)F]fluoro-d-glucose on intended management of patients with primary and metastatic brain tumors. PROCEDURES: We analyzed demographic characteristics and evaluated change in intended management after PET, using previously described metrics, for patients in the National Oncologic PET Registry (NOPR) undergoing dedicated brain PET. For cases of primary brain tumors, comparisons to the overall NOPR cohort were made. PATIENT PROFILE: Between December 2006 and April 2009, 509 dedicated brain PET scans were done on 479 patients—367 (72.1%) for suspected or proven primary brain tumors and 142 (27.9%) for brain metastases. Compared with the overall NOPR cohort, subjects in the dedicated brain cohort were younger (41.3% less than 65 years vs. 10.5% overall, p < 0.0001) and more frequently had functional limitations from their cancers (78.6% vs. 62.3% overall; odds ratio (OR) 2.2, 95% CI 1.8–2.8). RESULTS: The pre-PET patient management plans in the primary brain tumor and metastasis subgroups were similar. A pre-PET plan of tissue biopsy was slightly more frequent than one of the treatments (31.3% vs. 28.6%) in the primary brain tumor subgroup and was more common than in the overall NOPR cohort (14.2%; OR 2.8, 95% CI 2.2–3.5). Changes from treatment to non-treatment also were more frequent than in the overall NOPR cohort (13.4% vs. 7.7%; OR 1.9, 95% CI 1.3–2.5). CONCLUSIONS: Among NOPR patients, dedicated brain PET was associated with similar net changes in intended management as in the overall NOPR cohort. However, brain PET patients were younger, more likely to be symptomatic, and less likely to have a change in management from non-treatment to treatment as a post-PET plan. Springer-Verlag 2010-10-07 2011 /pmc/articles/PMC3023024/ /pubmed/21080232 http://dx.doi.org/10.1007/s11307-010-0427-5 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Research Article
Hillner, Bruce E.
Siegel, Barry A.
Shields, Anthony F.
Duan, Fenghai
Gareen, Ilana F.
Hanna, Lucy
Coleman, R. Edward
Impact of Dedicated Brain PET on Intended Patient Management in Participants of the National Oncologic PET Registry
title Impact of Dedicated Brain PET on Intended Patient Management in Participants of the National Oncologic PET Registry
title_full Impact of Dedicated Brain PET on Intended Patient Management in Participants of the National Oncologic PET Registry
title_fullStr Impact of Dedicated Brain PET on Intended Patient Management in Participants of the National Oncologic PET Registry
title_full_unstemmed Impact of Dedicated Brain PET on Intended Patient Management in Participants of the National Oncologic PET Registry
title_short Impact of Dedicated Brain PET on Intended Patient Management in Participants of the National Oncologic PET Registry
title_sort impact of dedicated brain pet on intended patient management in participants of the national oncologic pet registry
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023024/
https://www.ncbi.nlm.nih.gov/pubmed/21080232
http://dx.doi.org/10.1007/s11307-010-0427-5
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