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High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4(+) T cell responses
T cell affinity for antigen initiates adaptive immunity. However, the contribution of low affinity cells to a response is unknown as it has not been possible to assess the entire affinity range of a polyclonal T cell repertoire. In this study, we used a highly sensitive two-dimensional binding assay...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023139/ https://www.ncbi.nlm.nih.gov/pubmed/21220453 http://dx.doi.org/10.1084/jem.20101574 |