Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia

Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected...

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Autores principales: Nahimana, Aimable, Rabodonirina, Meja, Helweg-Larsen, Jannik, Meneau, Isabelle, Francioli, Patrick, Bille, Jacques, Hauser, Philippe M.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2003
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023424/
https://www.ncbi.nlm.nih.gov/pubmed/12890330
http://dx.doi.org/10.3201/eid0907.020753
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author Nahimana, Aimable
Rabodonirina, Meja
Helweg-Larsen, Jannik
Meneau, Isabelle
Francioli, Patrick
Bille, Jacques
Hauser, Philippe M.
author_facet Nahimana, Aimable
Rabodonirina, Meja
Helweg-Larsen, Jannik
Meneau, Isabelle
Francioli, Patrick
Bille, Jacques
Hauser, Philippe M.
author_sort Nahimana, Aimable
collection PubMed
description Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
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spelling pubmed-30234242011-01-27 Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia Nahimana, Aimable Rabodonirina, Meja Helweg-Larsen, Jannik Meneau, Isabelle Francioli, Patrick Bille, Jacques Hauser, Philippe M. Emerg Infect Dis Dispatch Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug. Centers for Disease Control and Prevention 2003-07 /pmc/articles/PMC3023424/ /pubmed/12890330 http://dx.doi.org/10.3201/eid0907.020753 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Nahimana, Aimable
Rabodonirina, Meja
Helweg-Larsen, Jannik
Meneau, Isabelle
Francioli, Patrick
Bille, Jacques
Hauser, Philippe M.
Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia
title Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia
title_full Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia
title_fullStr Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia
title_full_unstemmed Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia
title_short Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia
title_sort sulfa resistance and dihydropteroate synthase mutants in recurrent pneumocystis carinii pneumonia
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023424/
https://www.ncbi.nlm.nih.gov/pubmed/12890330
http://dx.doi.org/10.3201/eid0907.020753
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