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Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family

Alterations in genes involved in the repair of DNA mutations (mut genes) result in an increased mutation frequency and better adaptability of the bacterium to stressful conditions. W-Beijing genotype strains displayed unique missense alterations in three putative mut genes, including two of the mutT...

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Autores principales: Rad, Mina Ebrahimi, Bifani, Pablo, Martin, Carlos, Kremer, Kristin, Samper, Sofia, Rauzier, Jean, Kreiswirth, Barry, Blazquez, Jesus, Jouan, Marc, van Soolingen, Dick, Gicquel, Brigitte
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023437/
https://www.ncbi.nlm.nih.gov/pubmed/12890325
http://dx.doi.org/10.3201/eid0907.020803
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author Rad, Mina Ebrahimi
Bifani, Pablo
Martin, Carlos
Kremer, Kristin
Samper, Sofia
Rauzier, Jean
Kreiswirth, Barry
Blazquez, Jesus
Jouan, Marc
van Soolingen, Dick
Gicquel, Brigitte
author_facet Rad, Mina Ebrahimi
Bifani, Pablo
Martin, Carlos
Kremer, Kristin
Samper, Sofia
Rauzier, Jean
Kreiswirth, Barry
Blazquez, Jesus
Jouan, Marc
van Soolingen, Dick
Gicquel, Brigitte
author_sort Rad, Mina Ebrahimi
collection PubMed
description Alterations in genes involved in the repair of DNA mutations (mut genes) result in an increased mutation frequency and better adaptability of the bacterium to stressful conditions. W-Beijing genotype strains displayed unique missense alterations in three putative mut genes, including two of the mutT type (Rv3908 and mutT2) and ogt. These polymorphisms were found to be characteristic and unique to W-Beijing phylogenetic lineage. Analysis of the mut genes in 55 representative W-Beijing isolates suggests a sequential acquisition of the mutations, elucidating a plausible pathway of the molecular evolution of this clonal family. The acquisition of mut genes may explain in part the ability of the isolates of W-Beijing type to rapidly adapt to their environment.
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spelling pubmed-30234372011-01-27 Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family Rad, Mina Ebrahimi Bifani, Pablo Martin, Carlos Kremer, Kristin Samper, Sofia Rauzier, Jean Kreiswirth, Barry Blazquez, Jesus Jouan, Marc van Soolingen, Dick Gicquel, Brigitte Emerg Infect Dis Research Alterations in genes involved in the repair of DNA mutations (mut genes) result in an increased mutation frequency and better adaptability of the bacterium to stressful conditions. W-Beijing genotype strains displayed unique missense alterations in three putative mut genes, including two of the mutT type (Rv3908 and mutT2) and ogt. These polymorphisms were found to be characteristic and unique to W-Beijing phylogenetic lineage. Analysis of the mut genes in 55 representative W-Beijing isolates suggests a sequential acquisition of the mutations, elucidating a plausible pathway of the molecular evolution of this clonal family. The acquisition of mut genes may explain in part the ability of the isolates of W-Beijing type to rapidly adapt to their environment. Centers for Disease Control and Prevention 2003-07 /pmc/articles/PMC3023437/ /pubmed/12890325 http://dx.doi.org/10.3201/eid0907.020803 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Rad, Mina Ebrahimi
Bifani, Pablo
Martin, Carlos
Kremer, Kristin
Samper, Sofia
Rauzier, Jean
Kreiswirth, Barry
Blazquez, Jesus
Jouan, Marc
van Soolingen, Dick
Gicquel, Brigitte
Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family
title Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family
title_full Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family
title_fullStr Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family
title_full_unstemmed Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family
title_short Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family
title_sort mutations in putative mutator genes of mycobacterium tuberculosis strains of the w-beijing family
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023437/
https://www.ncbi.nlm.nih.gov/pubmed/12890325
http://dx.doi.org/10.3201/eid0907.020803
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