Hepatitis C virus genotype 3a with phylogenetically distinct origin is circulating in Pakistan

BACKGROUND: Hepatitis C virus (HCV) is one of the leading causes of viral hepatitis worldwide and its genotype 3a is predominant in vast areas of Pakistan. FINDINGS: The present study reports the first full sequence of HCV 3a isolate PK-1 from Pakistan. This nucleotide sequence was compared with six...

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Detalles Bibliográficos
Autores principales: Rehman, Irshad-ur, Idrees, Muhammad, Ali, Muhammad, Ali, Liaqat, Butt, Sadia, Hussain, Abrar, Akbar, Haji, Afzal, Samia
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023652/
https://www.ncbi.nlm.nih.gov/pubmed/21211024
http://dx.doi.org/10.1186/1479-0556-9-2
Descripción
Sumario:BACKGROUND: Hepatitis C virus (HCV) is one of the leading causes of viral hepatitis worldwide and its genotype 3a is predominant in vast areas of Pakistan. FINDINGS: The present study reports the first full sequence of HCV 3a isolate PK-1 from Pakistan. This nucleotide sequence was compared with six other HCV genotype 3a full length sequences from different regions of the world by using statistical methods of phylogenetic analysis. CONCLUSION: The nucleotide difference of these seven sequences shows that HCV genotype 3a of phylogenetically distinct origin is circulating in Pakistan.

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