6-Nitro-2-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis

BACKGROUND: Anticancer activities of several substituted naphthalimides (1H-benz[de]isoquinoline-1,3-diones) are well documented. Some of them have undergone Phase I-II clinical trials. Presently a series of ten N-(hydroxyalkyl) naphthalimides (compounds 1a-j) were evaluated as antitumor agents. MET...

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Detalles Bibliográficos
Autores principales: Mukherjee, Asama, Dutta, Sushanta, Shanmugavel, Muthiah, Mondhe, Dilip M, Sharma, Parduman R, Singh, Shashank K, Saxena, Ajit K, Sanyal, Utpal
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023684/
https://www.ncbi.nlm.nih.gov/pubmed/21194464
http://dx.doi.org/10.1186/1756-9966-29-175

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