The role of RhoA/Rho kinase pathway in endothelial dysfunction

Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstrict...

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Autores principales: Yao, Lin, Romero, Maritza J., Toque, Haroldo A., Yang, Guang, Caldwell, Ruth B, Caldwell, R. William
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023892/
https://www.ncbi.nlm.nih.gov/pubmed/21264179
http://dx.doi.org/10.4103/0975-3583.74258
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author Yao, Lin
Romero, Maritza J.
Toque, Haroldo A.
Yang, Guang
Caldwell, Ruth B
Caldwell, R. William
author_facet Yao, Lin
Romero, Maritza J.
Toque, Haroldo A.
Yang, Guang
Caldwell, Ruth B
Caldwell, R. William
author_sort Yao, Lin
collection PubMed
description Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.
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spelling pubmed-30238922011-01-24 The role of RhoA/Rho kinase pathway in endothelial dysfunction Yao, Lin Romero, Maritza J. Toque, Haroldo A. Yang, Guang Caldwell, Ruth B Caldwell, R. William J Cardiovasc Dis Res Invited Review Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction. Medknow Publications 2010 /pmc/articles/PMC3023892/ /pubmed/21264179 http://dx.doi.org/10.4103/0975-3583.74258 Text en © Journal of Cardiovascular Disease Research http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Review
Yao, Lin
Romero, Maritza J.
Toque, Haroldo A.
Yang, Guang
Caldwell, Ruth B
Caldwell, R. William
The role of RhoA/Rho kinase pathway in endothelial dysfunction
title The role of RhoA/Rho kinase pathway in endothelial dysfunction
title_full The role of RhoA/Rho kinase pathway in endothelial dysfunction
title_fullStr The role of RhoA/Rho kinase pathway in endothelial dysfunction
title_full_unstemmed The role of RhoA/Rho kinase pathway in endothelial dysfunction
title_short The role of RhoA/Rho kinase pathway in endothelial dysfunction
title_sort role of rhoa/rho kinase pathway in endothelial dysfunction
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023892/
https://www.ncbi.nlm.nih.gov/pubmed/21264179
http://dx.doi.org/10.4103/0975-3583.74258
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