Cargando…

Glycine Transport Inhibitors for the Treatment of Schizophrenia

Multiple lines of evidence indicate that hypofunction of glutamatergic neurotransmission via N-methyl-D-aspartate (NMDA) receptors might be implicated in the pathophysiology of schizophrenia, suggesting that increasing NMDA receptor function via pharmacological manipulation could provide a new strat...

Descripción completa

Detalles Bibliográficos
Autor principal:	Hashimoto, Kenji
Formato:	Texto
Lenguaje:	English
Publicado:	Bentham Open 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023951/ https://www.ncbi.nlm.nih.gov/pubmed/21253021 http://dx.doi.org/10.2174/1874104501004010010

Ejemplares similares

A comparison of the transport kinetics of glycine transporter 1 and glycine transporter 2
por: Erdem, Fatma Asli, et al.
Publicado: (2019)

In Vivo Evaluation of (11)C-labeled Three Radioligands for Glycine Transporter 1 in the Mouse Brain
por: Zhang, Ji-chun, et al.
Publicado: (2012)

Pharmacological Characterization of [(3)H]CHIBA-3007 Binding to Glycine Transporter 1 in the Rat Brain
por: Zhang, Jichun, et al.
Publicado: (2011)

A Role for Accumbal Glycine Receptors in Modulation of Dopamine Release by the Glycine Transporter-1 Inhibitor Org25935
por: Lidö, Helga Höifödt, et al.
Publicado: (2011)

Analysis of Binding Determinants for Different Classes of Competitive and Noncompetitive Inhibitors of Glycine Transporters
por: Łątka, Kamil, et al.
Publicado: (2022)

A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors
por: Sheipouri, Diba, et al.
Publicado: (2020)

Glycine Transporters and Receptors as Targets for Analgesics
por: Harvey, Robert J., et al.
Publicado: (2021)

Reconstitution of GABA, Glycine and Glutamate Transporters
por: Danbolt, Niels Christian, et al.
Publicado: (2021)

Screening for New Inhibitors of Glycine Transporter 1 and 2 by Means of MS Binding Assays
por: Ackermann, Thomas M., et al.
Publicado: (2021)

Cellular Transport and Membrane Dynamics of the Glycine Receptor
por: Dumoulin, Andrea, et al.
Publicado: (2010)

Glycine Transporter 2: Mechanism and Allosteric Modulation
por: Frangos, Zachary J., et al.
Publicado: (2021)

Structural Determinants of the Neuronal Glycine Transporter 2 for the Selective Inhibitors ALX1393 and ORG25543
por: Benito-Muñoz, Cristina, et al.
Publicado: (2021)

Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
por: Frangos, Zachary J, et al.
Publicado: (2023)

Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish population
por: Merk, Wojciech, et al.
Publicado: (2019)

Glycine Signaling in the Framework of Dopamine-Glutamate Interaction and Postsynaptic Density. Implications for Treatment-Resistant Schizophrenia
por: de Bartolomeis, Andrea, et al.
Publicado: (2020)

A glycine transporter 2-Cre knock-in mouse line for glycinergic neuron-specific gene manipulation
por: Kakizaki, Toshikazu, et al.
Publicado: (2017)

A Critical Role for Glycine Transporters in Hyperexcitability Disorders
por: Harvey, Robert J., et al.
Publicado: (2008)

Flux coupling, not specificity, shapes the transport and phylogeny of SLC6 glycine transporters
por: Le Guellec, Bastien, et al.
Publicado: (2022)

Glycinergic transmission: glycine transporter GlyT2 in neuronal pathologies
por: Zafra, Francisco, et al.
Publicado: (2016)

A double-blind randomized study assessing safety and efficacy following one-year adjunctive treatment with bitopertin, a glycine reuptake inhibitor, in Japanese patients with schizophrenia
por: Hirayasu, Yoshio, et al.
Publicado: (2016)

Oocyte-Specific Deletion of Slc6a9 Encoding the GLYT1 Glycine Transporter Eliminates Glycine Transport in Mouse Preimplantation Embryos and Their Ability to Counter Hypertonic Stress
por: Tscherner, Allison K., et al.
Publicado: (2023)

Calnexin-Assisted Biogenesis of the Neuronal Glycine Transporter 2 (GlyT2)
por: Arribas-González, Esther, et al.
Publicado: (2013)

Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker
por: Hashimoto, Kenji
Publicado: (2015)

α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer’s Disease
por: Toyohara, Jun, et al.
Publicado: (2010)

Computational study on single molecular spectroscopy of tyrosin-glycine, tryptophane-glycine and glycine-tryptophane
por: Yang, Bing, et al.
Publicado: (2017)

The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo
por: de la Rocha-Muñoz, Andrés, et al.
Publicado: (2021)

The pattern of Phosphate transporter 1 genes evolutionary divergence in Glycine max L.
por: Fan, Chengming, et al.
Publicado: (2013)

Glycine Transporter 1 Encephalopathy From Biochemical Pathway to Clinical Disease: Review
por: Alfallaj, Rayan, et al.
Publicado: (2019)

Ultrathin nucleoporin phenylalanine–glycine repeat films and their interaction with nuclear transport receptors
por: Eisele, Nico B, et al.
Publicado: (2010)

Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2
por: Mostyn, Shannon N., et al.
Publicado: (2020)

Metabolomic Variability of Different Soybean Genotypes: β-Carotene-Enhanced (Glycine max), Wild (Glycine soja), and Hybrid (Glycine max × Glycine soja) Soybeans
por: Jung, Jung-Won, et al.
Publicado: (2021)

Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor
por: Ito, Daishi, et al.
Publicado: (2020)

The phosphodiesterase-4 and glycine transporter-1 inhibitors enhance in vivo hippocampal theta network connectivity and synaptic plasticity, whereas D-serine does not
por: Ahnaou, A., et al.
Publicado: (2020)

Cross-Linking and Functional Analyses for Dimerization of a Cysteine Mutant of Glycine Transporter 1
por: Wang, Jingru, et al.
Publicado: (2022)

QSAR, ADME-Tox, molecular docking and molecular dynamics simulations of novel selective glycine transporter type 1 inhibitors with memory enhancing properties
por: El fadili, Mohamed, et al.
Publicado: (2023)

Identification of a 3(rd) Na(+) Binding Site of the Glycine Transporter, GlyT2
por: Subramanian, Nandhitha, et al.
Publicado: (2016)

Glycine and Glycine Receptor Signalling in Non-Neuronal Cells
por: den Eynden, Jimmy Van, et al.
Publicado: (2009)

The cardiometabolic benefits of glycine: Is glycine an ‘antidote’ to dietary fructose?
por: McCarty, Mark F, et al.
Publicado: (2014)

Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor
por: Desch, Michael, et al.
Publicado: (2021)

Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia
por: Deng, Xiangdong, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_rumtfd4nd3ngutefd0l2orofop