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1,000 structures and more from the MCSG

BACKGROUND: The Midwest Center for Structural Genomics (MCSG) is one of the large-scale centres of the Protein Structure Initiative (PSI). During the first two phases of the PSI the MCSG has solved over a thousand protein structures. A criticism of structural genomics is that target selection strate...

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Autores principales: Lee, David, de Beer, Tjaart AP, Laskowski, Roman A, Thornton, Janet M, Orengo, Christine A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024214/
https://www.ncbi.nlm.nih.gov/pubmed/21219649
http://dx.doi.org/10.1186/1472-6807-11-2
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author Lee, David
de Beer, Tjaart AP
Laskowski, Roman A
Thornton, Janet M
Orengo, Christine A
author_facet Lee, David
de Beer, Tjaart AP
Laskowski, Roman A
Thornton, Janet M
Orengo, Christine A
author_sort Lee, David
collection PubMed
description BACKGROUND: The Midwest Center for Structural Genomics (MCSG) is one of the large-scale centres of the Protein Structure Initiative (PSI). During the first two phases of the PSI the MCSG has solved over a thousand protein structures. A criticism of structural genomics is that target selection strategies mean that some structures are solved without having a known function and thus are of little biomedical significance. Structures of unknown function have stimulated the development of methods for function prediction from structure. RESULTS: We show that the MCSG has met the stated goals of the PSI and use online resources and readily available function prediction methods to provide functional annotations for more than 90% of the MCSG structures. The structure-to-function prediction method ProFunc provides likely functions for many of the MCSG structures that cannot be annotated by sequence-based methods. CONCLUSIONS: Although the focus of the PSI was structural coverage, many of the structures solved by the MCSG can also be associated with functional classes and biological roles of possible biomedical value.
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spelling pubmed-30242142011-01-21 1,000 structures and more from the MCSG Lee, David de Beer, Tjaart AP Laskowski, Roman A Thornton, Janet M Orengo, Christine A BMC Struct Biol Research Article BACKGROUND: The Midwest Center for Structural Genomics (MCSG) is one of the large-scale centres of the Protein Structure Initiative (PSI). During the first two phases of the PSI the MCSG has solved over a thousand protein structures. A criticism of structural genomics is that target selection strategies mean that some structures are solved without having a known function and thus are of little biomedical significance. Structures of unknown function have stimulated the development of methods for function prediction from structure. RESULTS: We show that the MCSG has met the stated goals of the PSI and use online resources and readily available function prediction methods to provide functional annotations for more than 90% of the MCSG structures. The structure-to-function prediction method ProFunc provides likely functions for many of the MCSG structures that cannot be annotated by sequence-based methods. CONCLUSIONS: Although the focus of the PSI was structural coverage, many of the structures solved by the MCSG can also be associated with functional classes and biological roles of possible biomedical value. BioMed Central 2011-01-10 /pmc/articles/PMC3024214/ /pubmed/21219649 http://dx.doi.org/10.1186/1472-6807-11-2 Text en Copyright ©2011 Lee et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lee, David
de Beer, Tjaart AP
Laskowski, Roman A
Thornton, Janet M
Orengo, Christine A
1,000 structures and more from the MCSG
title 1,000 structures and more from the MCSG
title_full 1,000 structures and more from the MCSG
title_fullStr 1,000 structures and more from the MCSG
title_full_unstemmed 1,000 structures and more from the MCSG
title_short 1,000 structures and more from the MCSG
title_sort 1,000 structures and more from the mcsg
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024214/
https://www.ncbi.nlm.nih.gov/pubmed/21219649
http://dx.doi.org/10.1186/1472-6807-11-2
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