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Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets
The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n = 139) and age-matched healthy individuals. The results show that CMV-seropositivity is associated with expansion of...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024293/ https://www.ncbi.nlm.nih.gov/pubmed/21214947 http://dx.doi.org/10.1186/1742-4933-8-2 |
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author | Litjens, Nicolle HR de Wit, Elly A Betjes, Michiel GH |
author_facet | Litjens, Nicolle HR de Wit, Elly A Betjes, Michiel GH |
author_sort | Litjens, Nicolle HR |
collection | PubMed |
description | The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n = 139) and age-matched healthy individuals. The results show that CMV-seropositivity is associated with expansion of both CD4(+ )and CD8(+ )memory T cells which is already observed in young healthy individuals. In addition, CMV-seropositive healthy individuals have a more differentiated memory T cell profile. Only CMV-seropositive healthy individuals showed an age-dependent decrease in CD4(+ )naïve T cells. The age-related decrease in the number of CD8(+ )naïve T cells was CMV-independent. In contrast, all ESRD patients showed a profound naïve T-cell lymphopenia at every decade. CMV-seropositivity aggravated the contraction of CD4(+ )naïve T cells and increased the number of differentiated CD4(+ )and CD8(+ )memory T cells. In conclusion, CMV-seropositivity markedly alters the homeostasis of circulating T cells in healthy individuals and aggravates the T cell dysregulation observed in ESRD patients. |
format | Text |
id | pubmed-3024293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30242932011-01-21 Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets Litjens, Nicolle HR de Wit, Elly A Betjes, Michiel GH Immun Ageing Research The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n = 139) and age-matched healthy individuals. The results show that CMV-seropositivity is associated with expansion of both CD4(+ )and CD8(+ )memory T cells which is already observed in young healthy individuals. In addition, CMV-seropositive healthy individuals have a more differentiated memory T cell profile. Only CMV-seropositive healthy individuals showed an age-dependent decrease in CD4(+ )naïve T cells. The age-related decrease in the number of CD8(+ )naïve T cells was CMV-independent. In contrast, all ESRD patients showed a profound naïve T-cell lymphopenia at every decade. CMV-seropositivity aggravated the contraction of CD4(+ )naïve T cells and increased the number of differentiated CD4(+ )and CD8(+ )memory T cells. In conclusion, CMV-seropositivity markedly alters the homeostasis of circulating T cells in healthy individuals and aggravates the T cell dysregulation observed in ESRD patients. BioMed Central 2011-01-08 /pmc/articles/PMC3024293/ /pubmed/21214947 http://dx.doi.org/10.1186/1742-4933-8-2 Text en Copyright ©2011 Litjens et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Litjens, Nicolle HR de Wit, Elly A Betjes, Michiel GH Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets |
title | Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets |
title_full | Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets |
title_fullStr | Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets |
title_full_unstemmed | Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets |
title_short | Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets |
title_sort | differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (esrd) on circulating t lymphocyte subsets |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024293/ https://www.ncbi.nlm.nih.gov/pubmed/21214947 http://dx.doi.org/10.1186/1742-4933-8-2 |
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