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Specific Binding of the Pathogenic Prion Isoform: Development and Characterization of a Humanized Single-Chain Variable Antibody Fragment

Murine monoclonal antibody V5B2 which specifically recognizes the pathogenic form of the prion protein represents a potentially valuable tool in diagnostics or therapy of prion diseases. As murine antibodies elicit immune response in human, only modified forms can be used for therapeutic application...

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Detalles Bibliográficos
Autores principales:	Škrlj, Nives, Vranac, Tanja, Popović, Mara, Čurin Šerbec, Vladka, Dolinar, Marko
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024399/ https://www.ncbi.nlm.nih.gov/pubmed/21283753 http://dx.doi.org/10.1371/journal.pone.0015783

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