Cargando…

Associative Learning Changes the Organization of Functional Excitatory Circuits Targeting the Supragranular Layers of Mouse Barrel Cortex

In primary sensory cortices, neuronal circuits change throughout life as a function of learning. During associative learning a neutral sensory stimulus acquires the emotional valence of an aversive event or a reward after repetitive contingent pairing. One important consequence is the enlargement of...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosselet, Céline, Fieschi, Maxime, Hugues, Sandrine, Bureau, Ingrid
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024829/
https://www.ncbi.nlm.nih.gov/pubmed/21267427
http://dx.doi.org/10.3389/fncir.2010.00126
_version_ 1782196816764207104
author Rosselet, Céline
Fieschi, Maxime
Hugues, Sandrine
Bureau, Ingrid
author_facet Rosselet, Céline
Fieschi, Maxime
Hugues, Sandrine
Bureau, Ingrid
author_sort Rosselet, Céline
collection PubMed
description In primary sensory cortices, neuronal circuits change throughout life as a function of learning. During associative learning a neutral sensory stimulus acquires the emotional valence of an aversive event or a reward after repetitive contingent pairing. One important consequence is the enlargement of the representational area of the conditioned stimulus in the cortical map of its sensory modality. The details of this phenomenon at the circuit level are still largely unknown. Here, mice were trained in a differential conditioning paradigm where the deflections of one whisker row were paired with tail shocks and the deflections of two others were not. Changes occurring in excitatory circuits of barrel cortex were then examined in brain slices with laser scanning photostimulation mapping. We found that learning affected the projections targeting the supragranular layers in the columns of unpaired whiskers: Pyramidal cells located in layer (L) 3 received enhanced inputs from L5A cells located in their home column and new inputs from L2/3 and L4 cells located in the neighboring column of the paired whisker. In contrast, the excitatory projections impinging onto L2/3 cells in the column of the paired whisker were not altered. Together, these data reveal that associative learning alters the canonical columnar organization of functional ascending L4 projections and strengthens transcolumnar excitatory projections in barrel cortex. These phenomena could participate to the transformation of the whisker somatotopic map induced by associative learning.
format Text
id pubmed-3024829
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Frontiers Research Foundation
record_format MEDLINE/PubMed
spelling pubmed-30248292011-01-25 Associative Learning Changes the Organization of Functional Excitatory Circuits Targeting the Supragranular Layers of Mouse Barrel Cortex Rosselet, Céline Fieschi, Maxime Hugues, Sandrine Bureau, Ingrid Front Neural Circuits Neuroscience In primary sensory cortices, neuronal circuits change throughout life as a function of learning. During associative learning a neutral sensory stimulus acquires the emotional valence of an aversive event or a reward after repetitive contingent pairing. One important consequence is the enlargement of the representational area of the conditioned stimulus in the cortical map of its sensory modality. The details of this phenomenon at the circuit level are still largely unknown. Here, mice were trained in a differential conditioning paradigm where the deflections of one whisker row were paired with tail shocks and the deflections of two others were not. Changes occurring in excitatory circuits of barrel cortex were then examined in brain slices with laser scanning photostimulation mapping. We found that learning affected the projections targeting the supragranular layers in the columns of unpaired whiskers: Pyramidal cells located in layer (L) 3 received enhanced inputs from L5A cells located in their home column and new inputs from L2/3 and L4 cells located in the neighboring column of the paired whisker. In contrast, the excitatory projections impinging onto L2/3 cells in the column of the paired whisker were not altered. Together, these data reveal that associative learning alters the canonical columnar organization of functional ascending L4 projections and strengthens transcolumnar excitatory projections in barrel cortex. These phenomena could participate to the transformation of the whisker somatotopic map induced by associative learning. Frontiers Research Foundation 2011-01-14 /pmc/articles/PMC3024829/ /pubmed/21267427 http://dx.doi.org/10.3389/fncir.2010.00126 Text en Copyright © 2011 Rosselet, Fieschi, Hugues and Bureau. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Rosselet, Céline
Fieschi, Maxime
Hugues, Sandrine
Bureau, Ingrid
Associative Learning Changes the Organization of Functional Excitatory Circuits Targeting the Supragranular Layers of Mouse Barrel Cortex
title Associative Learning Changes the Organization of Functional Excitatory Circuits Targeting the Supragranular Layers of Mouse Barrel Cortex
title_full Associative Learning Changes the Organization of Functional Excitatory Circuits Targeting the Supragranular Layers of Mouse Barrel Cortex
title_fullStr Associative Learning Changes the Organization of Functional Excitatory Circuits Targeting the Supragranular Layers of Mouse Barrel Cortex
title_full_unstemmed Associative Learning Changes the Organization of Functional Excitatory Circuits Targeting the Supragranular Layers of Mouse Barrel Cortex
title_short Associative Learning Changes the Organization of Functional Excitatory Circuits Targeting the Supragranular Layers of Mouse Barrel Cortex
title_sort associative learning changes the organization of functional excitatory circuits targeting the supragranular layers of mouse barrel cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024829/
https://www.ncbi.nlm.nih.gov/pubmed/21267427
http://dx.doi.org/10.3389/fncir.2010.00126
work_keys_str_mv AT rosseletceline associativelearningchangestheorganizationoffunctionalexcitatorycircuitstargetingthesupragranularlayersofmousebarrelcortex
AT fieschimaxime associativelearningchangestheorganizationoffunctionalexcitatorycircuitstargetingthesupragranularlayersofmousebarrelcortex
AT huguessandrine associativelearningchangestheorganizationoffunctionalexcitatorycircuitstargetingthesupragranularlayersofmousebarrelcortex
AT bureauingrid associativelearningchangestheorganizationoffunctionalexcitatorycircuitstargetingthesupragranularlayersofmousebarrelcortex