Cargando…
Survivin-T34A: molecular mechanism and therapeutic potential
The inhibitor of apoptosis protein survivin’s threonine 34 to alanine (T34A) mutation abolishes a phosphorylation site for p34(cdc2)–cyclin B1, resulting in initiation of the mitochondrial apoptotic pathway in cancer cells; however, it has little known direct effects on normal cells. The possibility...
| Autores principales: | , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024888/ https://www.ncbi.nlm.nih.gov/pubmed/21289859 http://dx.doi.org/10.2147/OTT.S15293 |