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CNV-WebStore: Online CNV Analysis, Storage and Interpretation
BACKGROUND: Microarray technology allows the analysis of genomic aberrations at an ever increasing resolution, making functional interpretation of these vast amounts of data the main bottleneck in routine implementation of high resolution array platforms, and emphasising the need for a centralised a...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024943/ https://www.ncbi.nlm.nih.gov/pubmed/21208430 http://dx.doi.org/10.1186/1471-2105-12-4 |
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author | Vandeweyer, Geert Reyniers, Edwin Wuyts, Wim Rooms, Liesbeth Kooy, R Frank |
author_facet | Vandeweyer, Geert Reyniers, Edwin Wuyts, Wim Rooms, Liesbeth Kooy, R Frank |
author_sort | Vandeweyer, Geert |
collection | PubMed |
description | BACKGROUND: Microarray technology allows the analysis of genomic aberrations at an ever increasing resolution, making functional interpretation of these vast amounts of data the main bottleneck in routine implementation of high resolution array platforms, and emphasising the need for a centralised and easy to use CNV data management and interpretation system. RESULTS: We present CNV-WebStore, an online platform to streamline the processing and downstream interpretation of microarray data in a clinical context, tailored towards but not limited to the Illumina BeadArray platform. Provided analysis tools include CNV analsyis, parent of origin and uniparental disomy detection. Interpretation tools include data visualisation, gene prioritisation, automated PubMed searching, linking data to several genome browsers and annotation of CNVs based on several public databases. Finally a module is provided for uniform reporting of results. CONCLUSION: CNV-WebStore is able to present copy number data in an intuitive way to both lab technicians and clinicians, making it a useful tool in daily clinical practice. |
format | Text |
id | pubmed-3024943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30249432011-01-22 CNV-WebStore: Online CNV Analysis, Storage and Interpretation Vandeweyer, Geert Reyniers, Edwin Wuyts, Wim Rooms, Liesbeth Kooy, R Frank BMC Bioinformatics Software BACKGROUND: Microarray technology allows the analysis of genomic aberrations at an ever increasing resolution, making functional interpretation of these vast amounts of data the main bottleneck in routine implementation of high resolution array platforms, and emphasising the need for a centralised and easy to use CNV data management and interpretation system. RESULTS: We present CNV-WebStore, an online platform to streamline the processing and downstream interpretation of microarray data in a clinical context, tailored towards but not limited to the Illumina BeadArray platform. Provided analysis tools include CNV analsyis, parent of origin and uniparental disomy detection. Interpretation tools include data visualisation, gene prioritisation, automated PubMed searching, linking data to several genome browsers and annotation of CNVs based on several public databases. Finally a module is provided for uniform reporting of results. CONCLUSION: CNV-WebStore is able to present copy number data in an intuitive way to both lab technicians and clinicians, making it a useful tool in daily clinical practice. BioMed Central 2011-01-05 /pmc/articles/PMC3024943/ /pubmed/21208430 http://dx.doi.org/10.1186/1471-2105-12-4 Text en Copyright © 2011 Vandeweyer et al; licensee BioMed Central Ltd. https://creativecommons.org/licenses/by/2.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0 (https://creativecommons.org/licenses/by/2.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Software Vandeweyer, Geert Reyniers, Edwin Wuyts, Wim Rooms, Liesbeth Kooy, R Frank CNV-WebStore: Online CNV Analysis, Storage and Interpretation |
title | CNV-WebStore: Online CNV Analysis, Storage and Interpretation |
title_full | CNV-WebStore: Online CNV Analysis, Storage and Interpretation |
title_fullStr | CNV-WebStore: Online CNV Analysis, Storage and Interpretation |
title_full_unstemmed | CNV-WebStore: Online CNV Analysis, Storage and Interpretation |
title_short | CNV-WebStore: Online CNV Analysis, Storage and Interpretation |
title_sort | cnv-webstore: online cnv analysis, storage and interpretation |
topic | Software |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024943/ https://www.ncbi.nlm.nih.gov/pubmed/21208430 http://dx.doi.org/10.1186/1471-2105-12-4 |
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