Directed evolution of a three-finger neurotoxin by using cDNA display yields antagonists as well as agonists of interleukin-6 receptor signaling

BACKGROUND: Directed evolution of biomolecules such as DNA, RNA and proteins containing high diversity has emerged as an effective method to obtain molecules for various purposes. In the recent past, proteins from non-immunoglobulins have attracted attention as they mimic antibodies with respect to...

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Detalles Bibliográficos
Autores principales: Naimuddin, Mohammed, Kobayashi, Suzuko, Tsutsui, Chihiro, Machida, Masayuki, Nemoto, Naoto, Sakai, Takafumi, Kubo, Tai
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024951/
https://www.ncbi.nlm.nih.gov/pubmed/21214917
http://dx.doi.org/10.1186/1756-6606-4-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024951/
https://www.ncbi.nlm.nih.gov/pubmed/21214917
http://dx.doi.org/10.1186/1756-6606-4-2

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