Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans

An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American an...

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Detalles Bibliográficos
Autores principales: King, Katherine Y., Lew, Justin D., Ha, Ngan P., Lin, Jeffery S., Ma, Xin, Graviss, Edward A., Goodell, Margaret A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025014/
https://www.ncbi.nlm.nih.gov/pubmed/21283700
http://dx.doi.org/10.1371/journal.pone.0016317
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author King, Katherine Y.
Lew, Justin D.
Ha, Ngan P.
Lin, Jeffery S.
Ma, Xin
Graviss, Edward A.
Goodell, Margaret A.
author_facet King, Katherine Y.
Lew, Justin D.
Ha, Ngan P.
Lin, Jeffery S.
Ma, Xin
Graviss, Edward A.
Goodell, Margaret A.
author_sort King, Katherine Y.
collection PubMed
description An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17–2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.
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spelling pubmed-30250142011-01-31 Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans King, Katherine Y. Lew, Justin D. Ha, Ngan P. Lin, Jeffery S. Ma, Xin Graviss, Edward A. Goodell, Margaret A. PLoS One Research Article An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17–2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans. Public Library of Science 2011-01-21 /pmc/articles/PMC3025014/ /pubmed/21283700 http://dx.doi.org/10.1371/journal.pone.0016317 Text en King et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
King, Katherine Y.
Lew, Justin D.
Ha, Ngan P.
Lin, Jeffery S.
Ma, Xin
Graviss, Edward A.
Goodell, Margaret A.
Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
title Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
title_full Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
title_fullStr Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
title_full_unstemmed Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
title_short Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
title_sort polymorphic allele of human irgm1 is associated with susceptibility to tuberculosis in african americans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025014/
https://www.ncbi.nlm.nih.gov/pubmed/21283700
http://dx.doi.org/10.1371/journal.pone.0016317
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