Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

Kinetochores assemble on distinct ‘centrochromatin' containing the histone H3 variant CENP-A and interspersed nucleosomes dimethylated on H3K4 (H3K4me2). Little is known about how the chromatin environment at active centromeres governs centromeric structure and function. Here, we report that ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Bergmann, Jan H, Rodríguez, Mariluz Gómez, Martins, Nuno M C, Kimura, Hiroshi, Kelly, David A, Masumoto, Hiroshi, Larionov, Vladimir, Jansen, Lars E T, Earnshaw, William C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025471/
https://www.ncbi.nlm.nih.gov/pubmed/21157429
http://dx.doi.org/10.1038/emboj.2010.329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025471/
https://www.ncbi.nlm.nih.gov/pubmed/21157429
http://dx.doi.org/10.1038/emboj.2010.329

Ejemplares similares