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The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes
BACKGROUND: Reactive astrocytes are capable of producing a variety of pro-inflammatory mediators and potentially neurotoxic compounds, including nitric oxide (NO). High amounts of NO are synthesized following up-regulation of inducible NO synthase (iNOS). The expression of iNOS is tightly regulated...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025854/ https://www.ncbi.nlm.nih.gov/pubmed/21208419 http://dx.doi.org/10.1186/1742-2094-8-1 |