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Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model

BACKGROUND: Hedgehog signalling has been implicated in prostate tumorigenesis in human subjects and mouse models, but its effects on transforming normal basal/stem cells toward malignant cancer stem cells remain poorly understood. METHODS: We produced pCX-shh-IG mice that overexpress Hedgehog protei...

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Detalles Bibliográficos
Autores principales:	Chang, Han-Hsin, Chen, Bo-Yie, Wu, Chia-Yung, Tsao, Zih-Jay, Chen, Ying-Yu, Chang, Chin-Pao, Yang, Chi-Rei, Lin, David Pei-Cheng
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025942/ https://www.ncbi.nlm.nih.gov/pubmed/21241512 http://dx.doi.org/10.1186/1423-0127-18-6

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