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Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression
BACKGROUND: SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elev...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025974/ https://www.ncbi.nlm.nih.gov/pubmed/21211030 http://dx.doi.org/10.1186/1476-4598-10-2 |