Cargando…

Balancing selection in the extended MHC region maintains a subset of alleles with opposite risk profile for different autoimmune diseases

Detalles Bibliográficos
Autores principales:	Cagliani, Rachele, Riva, Stefania, Fumagalli, Matteo, Pozzoli, Uberto, Comi, Giacomo P, Bresolin, Nereo, Clerici, Mario, Sironi, Manuela
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Poster Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026268/ http://dx.doi.org/10.1186/gb-2010-11-s1-p38

Ejemplares similares

Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving
por: Cagliani, Rachele, et al.
Publicado: (2011)

Genome-Wide Identification of Susceptibility Alleles for Viral Infections through a Population Genetics Approach
por: Fumagalli, Matteo, et al.
Publicado: (2010)

Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions
por: Fumagalli, Matteo, et al.
Publicado: (2009)

The landscape of human genes involved in the immune response to parasitic worms
por: Fumagalli, Matteo, et al.
Publicado: (2010)

The signature of long-standing balancing selection at the human defensin β-1 promoter
por: Cagliani, Rachele, et al.
Publicado: (2008)

A complex selection signature at the human AVPR1B gene
por: Cagliani, Rachele, et al.
Publicado: (2009)

Both selective and neutral processes drive GC content evolution in the human genome
por: Pozzoli, Uberto, et al.
Publicado: (2008)

Gene function and expression level influence the insertion/fixation dynamics of distinct transposon families in mammalian introns
por: Sironi, Manuela, et al.
Publicado: (2006)

OASes and STING: Adaptive Evolution in Concert
por: Mozzi, Alessandra, et al.
Publicado: (2015)

Genetic adaptation of the human circadian clock to day-length latitudinal variations and relevance for affective disorders
por: Forni, Diego, et al.
Publicado: (2014)

The evolutionary history of genes involved in spoken and written language: beyond FOXP2
por: Mozzi, Alessandra, et al.
Publicado: (2016)

Albuminoid Genes: Evolving at the Interface of Dispensability and Selection
por: Mozzi, Alessandra, et al.
Publicado: (2014)

Natural Selection at the Brush-Border: Adaptations to Carbohydrate Diets in Humans and Other Mammals
por: Pontremoli, Chiara, et al.
Publicado: (2015)

Evolutionary analysis of exogenous and integrated HHV-6A/HHV-6B populations
por: Forni, Diego, et al.
Publicado: (2020)

A complex evolutionary relationship between HHV-6A and HHV-6B
por: Forni, Diego, et al.
Publicado: (2019)

Retraction to: A complex evolutionary relationship between HHV-6A and HHV-6B
por: Forni, Diego, et al.
Publicado: (2019)

Identification of a new susceptibility variant for multiple sclerosis in OAS1 by population genetics analysis
por: Cagliani, Rachele, et al.
Publicado: (2011)

An Evolutionary Analysis of Antigen Processing and Presentation across Different Timescales Reveals Pervasive Selection
por: Forni, Diego, et al.
Publicado: (2014)

Ancient Evolution of Mammarenaviruses: Adaptation via Changes in the L Protein and No Evidence for Host–Virus Codivergence
por: Forni, Diego, et al.
Publicado: (2018)

Evolutionary rates of mammalian telomere-stability genes correlate with karyotype features and female germline expression
por: Pontremoli, Chiara, et al.
Publicado: (2018)

Multiple Selected Changes May Modulate the Molecular Interaction between Laverania RH5 and Primate Basigin
por: Forni, Diego, et al.
Publicado: (2018)

Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders
por: Mozzi, Alessandra, et al.
Publicado: (2017)

Intrinsically disordered regions are abundant in simplexvirus proteomes and display signatures of positive selection
por: Mozzi, Alessandra, et al.
Publicado: (2020)

Ancient and Recent Selective Pressures Shaped Genetic Diversity at AIM2-Like Nucleic Acid Sensors
por: Cagliani, Rachele, et al.
Publicado: (2014)

An APOBEC3 Mutational Signature in the Genomes of Human-Infecting Orthopoxviruses
por: Forni, Diego, et al.
Publicado: (2023)

Antigenic variation of SARS‐CoV‐2 in response to immune pressure
por: Forni, Diego, et al.
Publicado: (2020)

Evolutionary Analysis Provides Insight Into the Origin and Adaptation of HCV
por: Forni, Diego, et al.
Publicado: (2018)

Dating the Emergence of Human Endemic Coronaviruses
por: Forni, Diego, et al.
Publicado: (2022)

The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses
por: Forni, Diego, et al.
Publicado: (2015)

Adaptation of the endemic coronaviruses HCoV-OC43 and HCoV-229E to the human host
por: Forni, Diego, et al.
Publicado: (2021)

Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes
por: Al-Daghri, Nasser M, et al.
Publicado: (2012)

Selective events at individual sites underlie the evolution of monkeypox virus clades
por: Molteni, Cristian, et al.
Publicado: (2023)

Past and ongoing adaptation of human cytomegalovirus to its host
por: Mozzi, Alessandra, et al.
Publicado: (2020)

A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis
por: Guerini, Franca Rosa, et al.
Publicado: (2012)

Simplexviruses Successfully Adapt to Their Host by Fine-Tuning Immune Responses
por: Mozzi, Alessandra, et al.
Publicado: (2022)

The CCR5Δ32 allele is not a major predisposing factor for severe H1N1pdm09 infection
por: Sironi, Manuela, et al.
Publicado: (2014)

Nonstructural Proteins Are Preferential Positive Selection Targets in Zika Virus and Related Flaviviruses
por: Sironi, Manuela, et al.
Publicado: (2016)

Origin and dispersal of Hepatitis E virus
por: Forni, Diego, et al.
Publicado: (2018)

Genetic conflicts with Plasmodium parasites and functional constraints shape the evolution of erythrocyte cytoskeletal proteins
por: Sironi, Manuela, et al.
Publicado: (2018)

Computational Inference of Selection Underlying the Evolution of the Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2
por: Cagliani, Rachele, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9lv3u55lail1qa9vs6hfq5g8mo