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Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis
Mouse mammary tumor virus (MMTV), which was discovered as a milk-transmitted, infectious cancer-inducing agent in the 1930s, has been used since that time as an animal model for the study of human breast cancer. Like other complex retroviruses, MMTV encodes a number of accessory proteins that both f...
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026287/ https://www.ncbi.nlm.nih.gov/pubmed/21274409 http://dx.doi.org/10.3390/v2092000 |
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author | Ross, Susan R. |
author_facet | Ross, Susan R. |
author_sort | Ross, Susan R. |
collection | PubMed |
description | Mouse mammary tumor virus (MMTV), which was discovered as a milk-transmitted, infectious cancer-inducing agent in the 1930s, has been used since that time as an animal model for the study of human breast cancer. Like other complex retroviruses, MMTV encodes a number of accessory proteins that both facilitate infection and affect host immune response. In vivo, the virus predominantly infects lymphocytes and mammary epithelial cells. High level infection of mammary epithelial cells ensures efficient passage of virus to the next generation. It also results in mammary tumor induction, since the MMTV provirus integrates into the mammary epithelial cell genome during viral replication and activates cellular oncogene expression. Thus, mammary tumor induction is a by-product of the infection cycle. A number of important oncogenes have been discovered by carrying out MMTV integration site analysis, some of which may play a role in human breast cancer. |
format | Text |
id | pubmed-3026287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-30262872011-01-25 Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis Ross, Susan R. Viruses Review Mouse mammary tumor virus (MMTV), which was discovered as a milk-transmitted, infectious cancer-inducing agent in the 1930s, has been used since that time as an animal model for the study of human breast cancer. Like other complex retroviruses, MMTV encodes a number of accessory proteins that both facilitate infection and affect host immune response. In vivo, the virus predominantly infects lymphocytes and mammary epithelial cells. High level infection of mammary epithelial cells ensures efficient passage of virus to the next generation. It also results in mammary tumor induction, since the MMTV provirus integrates into the mammary epithelial cell genome during viral replication and activates cellular oncogene expression. Thus, mammary tumor induction is a by-product of the infection cycle. A number of important oncogenes have been discovered by carrying out MMTV integration site analysis, some of which may play a role in human breast cancer. Molecular Diversity Preservation International (MDPI) 2010-09-23 /pmc/articles/PMC3026287/ /pubmed/21274409 http://dx.doi.org/10.3390/v2092000 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Ross, Susan R. Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis |
title | Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis |
title_full | Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis |
title_fullStr | Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis |
title_full_unstemmed | Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis |
title_short | Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis |
title_sort | mouse mammary tumor virus molecular biology and oncogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026287/ https://www.ncbi.nlm.nih.gov/pubmed/21274409 http://dx.doi.org/10.3390/v2092000 |
work_keys_str_mv | AT rosssusanr mousemammarytumorvirusmolecularbiologyandoncogenesis |