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Virus assembly, allostery and antivirals
Assembly of virus capsids and surface proteins must be regulated to ensure that the resulting complex is an infectious virion. In this review, we examine assembly of virus capsids, focusing on hepatitis B virus and bacteriophage MS2, and formation of glycoproteins in the alphaviruses. These systems...
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Formato: | Texto |
Lenguaje: | English |
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Elsevier Ltd.
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026312/ https://www.ncbi.nlm.nih.gov/pubmed/21163649 http://dx.doi.org/10.1016/j.tim.2010.11.003 |
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author | Zlotnick, Adam Mukhopadhyay, Suchetana |
author_facet | Zlotnick, Adam Mukhopadhyay, Suchetana |
author_sort | Zlotnick, Adam |
collection | PubMed |
description | Assembly of virus capsids and surface proteins must be regulated to ensure that the resulting complex is an infectious virion. In this review, we examine assembly of virus capsids, focusing on hepatitis B virus and bacteriophage MS2, and formation of glycoproteins in the alphaviruses. These systems are structurally and biochemically well-characterized and are simplest-case paradigms of self-assembly. Published data suggest that capsid and glycoprotein assembly is subject to allosteric regulation, that is regulation at the level of conformational change. The hypothesis that allostery is a common theme in viruses suggests that deregulation of capsid and glycoprotein assembly by small molecule effectors will be an attractive antiviral strategy, as has been demonstrated with hepatitis B virus. |
format | Text |
id | pubmed-3026312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-30263122012-01-01 Virus assembly, allostery and antivirals Zlotnick, Adam Mukhopadhyay, Suchetana Trends Microbiol Article Assembly of virus capsids and surface proteins must be regulated to ensure that the resulting complex is an infectious virion. In this review, we examine assembly of virus capsids, focusing on hepatitis B virus and bacteriophage MS2, and formation of glycoproteins in the alphaviruses. These systems are structurally and biochemically well-characterized and are simplest-case paradigms of self-assembly. Published data suggest that capsid and glycoprotein assembly is subject to allosteric regulation, that is regulation at the level of conformational change. The hypothesis that allostery is a common theme in viruses suggests that deregulation of capsid and glycoprotein assembly by small molecule effectors will be an attractive antiviral strategy, as has been demonstrated with hepatitis B virus. Elsevier Ltd. 2011-01 2010-12-14 /pmc/articles/PMC3026312/ /pubmed/21163649 http://dx.doi.org/10.1016/j.tim.2010.11.003 Text en Copyright © 2010 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Zlotnick, Adam Mukhopadhyay, Suchetana Virus assembly, allostery and antivirals |
title | Virus assembly, allostery and antivirals |
title_full | Virus assembly, allostery and antivirals |
title_fullStr | Virus assembly, allostery and antivirals |
title_full_unstemmed | Virus assembly, allostery and antivirals |
title_short | Virus assembly, allostery and antivirals |
title_sort | virus assembly, allostery and antivirals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026312/ https://www.ncbi.nlm.nih.gov/pubmed/21163649 http://dx.doi.org/10.1016/j.tim.2010.11.003 |
work_keys_str_mv | AT zlotnickadam virusassemblyallosteryandantivirals AT mukhopadhyaysuchetana virusassemblyallosteryandantivirals |