Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption

Acrylonitrile is an IARC class 2B carcinogen present in cigarette smoke. Urinary 2-cyanoethylmercapturic acid (CEMA) is an acrylonitrile metabolite and a potential biomarker for acrylonitrile exposure. The objective of this work was to study the dose response of CEMA in urine of non-smokers and smok...

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Detalles Bibliográficos
Autores principales: Minet, Emmanuel, Cheung, Francis, Errington, Graham, Sterz, Katharina, Scherer, Gerhard
Formato: Texto
Lenguaje:English
Publicado: Informa Healthcare 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026342/
https://www.ncbi.nlm.nih.gov/pubmed/21108560
http://dx.doi.org/10.3109/1354750X.2010.533287
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author Minet, Emmanuel
Cheung, Francis
Errington, Graham
Sterz, Katharina
Scherer, Gerhard
author_facet Minet, Emmanuel
Cheung, Francis
Errington, Graham
Sterz, Katharina
Scherer, Gerhard
author_sort Minet, Emmanuel
collection PubMed
description Acrylonitrile is an IARC class 2B carcinogen present in cigarette smoke. Urinary 2-cyanoethylmercapturic acid (CEMA) is an acrylonitrile metabolite and a potential biomarker for acrylonitrile exposure. The objective of this work was to study the dose response of CEMA in urine of non-smokers and smokers of different ISO tar yield cigarettes. We observed that smokers excreted >100-fold higher amounts of urinary CEMA than non-smokers. The CEMA levels in smokers were significantly correlated with ISO tar yield, daily cigarette consumption, and urinary biomarkers of smoke exposure. In conclusion, urinary CEMA is a suitable biomarker for assessing smoking-related exposure to acrylonitrile.
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spelling pubmed-30263422011-01-31 Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption Minet, Emmanuel Cheung, Francis Errington, Graham Sterz, Katharina Scherer, Gerhard Biomarkers Original Article Acrylonitrile is an IARC class 2B carcinogen present in cigarette smoke. Urinary 2-cyanoethylmercapturic acid (CEMA) is an acrylonitrile metabolite and a potential biomarker for acrylonitrile exposure. The objective of this work was to study the dose response of CEMA in urine of non-smokers and smokers of different ISO tar yield cigarettes. We observed that smokers excreted >100-fold higher amounts of urinary CEMA than non-smokers. The CEMA levels in smokers were significantly correlated with ISO tar yield, daily cigarette consumption, and urinary biomarkers of smoke exposure. In conclusion, urinary CEMA is a suitable biomarker for assessing smoking-related exposure to acrylonitrile. Informa Healthcare 2011-02 2010-11-25 /pmc/articles/PMC3026342/ /pubmed/21108560 http://dx.doi.org/10.3109/1354750X.2010.533287 Text en Copyright © 2011 Informa UK, Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Informa Healthcare journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Minet, Emmanuel
Cheung, Francis
Errington, Graham
Sterz, Katharina
Scherer, Gerhard
Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption
title Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption
title_full Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption
title_fullStr Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption
title_full_unstemmed Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption
title_short Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption
title_sort urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026342/
https://www.ncbi.nlm.nih.gov/pubmed/21108560
http://dx.doi.org/10.3109/1354750X.2010.533287
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